NHLBI Animal Program Division

动物资源管理 除了手术和表型鉴定核心，NHLBI动物项目还为NHLBI运营设施中的啮齿动物提供兽医护理、研究技术支持和动物饲养，并监督NIH其他设施中的NHLBI动物活动。这包括物流和财务管理以及所有NHLBI动物活动的法规遵从性。 霍金斯博士、施普林格博士和乔妮·泰勒女士也是NHLBI动物护理和使用委员会的成员，该委员会负责动物研究活动的研究用途和法规遵从性。 霍金斯和斯普林格博士以及项目经理还协助研究人员规划研究项目、准备动物方案和实施工作。 外科核心科学影响 NHLBI导演奖，2015年12月 Karen Keeran、Gayle Nugent和Ken Jeffries获得了杰出翻译科学奖，表彰了DNA依赖蛋白激酶在树突状细胞功能中的作用，并确定了DNA-PK的药理抑制剂作为哮喘的新疗法。 在DIR内进行培训 ASR为所有在NHLBI从事动物手术的研究人员提供4小时的正式培训课程。我们在正式课程和一对一的环境中为调查人员提供外科培训。在过去的12个月里，我们在我们的调查人员培训课程中，正式培训了33名调查人员和技术人员，学习基本手术技能和无菌技术。 校外DIR教学与辅导 在过去的16年里，Robert Hoyt博士(前NHLBI，现在在NCI工作)领导和ASR工作人员担任美国实验动物科学协会(AALAS)多个显微外科车间湿实验室(基础和高级)的讲师。这次旅行由AALAS赞助和支付。这是他们最受欢迎和评价最高的研讨会之一。2015年ASR的讲师是Clevenger，Jeffries，Keeran，Kozlov，Nugent和San。 2015年，霍伊特博士、兰迪·克莱文格、乔尼·泰勒和ASR工作人员为NIH的工作人员举办了为期一天的显微外科研讨会。其中一个课程包括基本显微外科技术(9名学生)和一个8名学生的高级班。来自NHLBI以外的8名学生被收取了课程费用。我们计划继续提供这项服务，并将其视为NIH的宝贵培训机会。 2015年，Karen Keeran，Art Zetts，Ken Jeffries和Randy Clevenger在Area NCAB-AALAS缝合技术会议上讲授缝合技术。ASR的工作人员还在2016年教授了由NCAB赞助的校园缝合研讨会。 霍金斯博士在ASR工作人员的支持下，于2015年6月为密歇根大学实验室动物住院医生珍妮弗·贝宁森博士提供了为期两周的外部实习。我们2015年的暑期学生是传奇瑟曼女士。 吉本斯博士为带你的孩子上班日颁发的奖项包括：艾伦、克莱文杰、杰弗里斯、基兰、野口、斯普林格、泽茨

ANIMAL RESOURCES MANAGEMENT In addition to the surgery and phenotyping cores, the NHLBI animal program provides veterinary care, research technical support and animal husbandry to rodents in NHLBI operated facilities and oversight of NHLBI animal activities in other NIH facilities. This includes logistical and financial management as well as regulatory compliance for all NHLBI animal activities. Dr. Hawkins, Dr. Springer and Ms. Joni Taylor also serve as members of the NHLBI Animal Care and Use Committee which is responsible for the research use and regulatory compliance of the animal research activities. Drs Hawkins and Springer and the program managers also assist investigators in the planning of research projects, preparation of animal protocols and implementation of the work. SURGERY CORE SCIENTIFIC IMPACT NHLBI Directors Awards, December 2015 Outstanding Translational Science Award for characterizing a role for DNA-dependent protein kinase in dendritic cell function and identifying a pharmacological inhibitor of DNA-PK as a novel treatment for asthma, Karen Keeran, Gayle Nugent and Ken Jeffries. Training within DIR ASR provides a formal 4 hour training class for all research staff who do animal surgery in NHLBI. We provide investigators with surgical training both within formal classes and in one-on-one settings. Over the past 12 months, we have formally trained 33 investigators and technical staff in basic surgical skills and aseptic technique in our investigator training course. Outside DIR Teaching & Mentoring For the last 16 years, Dr. Robert Hoyt (formerly NHLBI and now in NCI) has led and the ASR staff has served as instructors for multiple microsurgical workshop wet-labs (basic and advanced) at the American Association for Laboratory Animal Science (AALAS). The travel for this is sponsored and paid for by AALAS. This is one of their most popular and highly rated workshops. Instructors from ASR in 2015 were Clevenger, Jeffries, Keeran, Kozlov, Nugent and San. In 2015, Dr. Hoyt, Randy Clevenger, Joni Taylor and the ASR staff conducted day-long microsurgery workshops for staff at NIH. One session covered basic microsurgical techniques (9 students) and one advanced class of 8 students. The 8 students from outside of NHLBI were charged for the classes. We plan to continue this offering and see it as a valuable training opportunity for NIH. Karen Keeran, Art Zetts, Ken Jeffries and Randy Clevenger taught a workshop at the area NCAB-AALAS conference on suturing technique in 2015. ASR staff also taught an on-campus suturing workshop sponsored by NCAB in 2016. Dr. Hawkins with ASR staff support, provided a 2 week externship in June 2015 for Dr. Jennifer Beninson from the University of Michigan lab animal residency program. Our summer student for 2015 was Ms. Legend Thurman. An award from Dr. Gibbons for Take Your Child to Work Day was provided for: Allen, Clevenger, Jeffries, Keeran, Noguchi, Springer, Zetts