Vanderbilt Center for Diabetes Translation Research

中心概述项目摘要/摘要 临床试验已经证实，血糖控制和心血管危险因素修改可以降低 1型和2型糖尿病并发症的风险。此外，行为策略已被证明会延迟 或预防糖尿病高危人群患2型糖尿病。尽管清楚地表明 有证据表明，许多糖尿病患者没有达到糖尿病护理的推荐目标。有一个 证据和现实世界的糖尿病预防和治疗之间存在明确的差距，这种差距尤其明显 在许多种族和少数民族中都很明显。 范德比尔特大学医学中心和梅哈里医学院的调查人员提议续签 我们的糖尿病翻译研究中心(https://labnodes.vanderbilt.edu/cdtr)通过以下方式弥合这一差距 以我们在第二类翻译研究方面的成功为基础。这项续订提案是基于一项富有成效的 最初的五年和下一个周期的计划，以保持我们出色的领导力的连续性，同时 引入变革，以反映我们研究基础不断变化的需求。在过去的五年里，我们的研究 基数显著扩大(从23个增加到38个)，资金充足(仅来自NIDDK的年度直接成本 近500万)，并出版了重要手稿(被引用136篇)。我们的P&F计划已经非常 成功(8名调查员资助30K/年，为期两年)，因为4名调查员已经收到 无论是K奖还是DP3奖，第五名获奖者都获得了RO1。我们相信我们的P&F计划， 以机构配套资金的杠杆能力和延长两年的能力，一直是 该中心最成功的方面。我们的丰富计划是广泛的，包括合作 校园内有多个实体。 我们建议在过去五年的卓越基础上，保持我们的核心结构和 领导力，同时引入新的核心(行为干预技术和服务核心)和领导者 (钱德拉·奥斯本博士)以反映利用技术进行行为研究的不断扩大的研究基础 干预措施。我们通过与Meharry的长期关系保持对健康差距的关注 医学院，并在此基础上引入一位新的领导人(Consuelo Wilkins，M.D.)领导我们的 浓缩核。威尔金斯博士领导梅哈里-范德比尔特联盟(https://medschool.vanderbilt.edu/meharry- Vanderbilt/)，这一明确促进了我们两个机构之间的合作，以促进临床和 社区参与的协作、教育和研究。这些增加的内容建立在我们减少 在扩大我们推进行为干预技术知识的努力的同时，我们也在扩大健康差距。

Center Overview Project Summary/Abstract Clinical trials have established that glycemic control and cardiovascular risk factor modification can reduce the risk of complications of type 1 and type 2 diabetes. In addition, behavioral strategies have been shown to delay or prevent the development of type 2 diabetes in individuals at high risk for diabetes. Despite the clarity of evidence, many individuals with diabetes do not meet the recommended goals of diabetes care. There is an unequivocal gap between evidence and real-world diabetes prevention and treatment, and this gap is particular evident in many racial and ethnic minorities. Investigators at the Vanderbilt University Medical Center and Meharry Medical College propose a renewal to our Center for Diabetes Translation Research ( https://labnodes.vanderbilt.edu/cdtr ) to bridge this gap by building on our success in type II translation research. This renewal proposal is based on a highly productive initial five years and a plan for the next cycle that maintains continuity with our excellent leadership while introducing change to reflect the changing needs of our research base. During the past five years our research base has significantly enlarged (from 23 to 38), been well funded (annual direct costs from NIDDK alone of nearly five million), and published important manuscripts (136 cited). Our P&F program has been extremely successful (8 investigators funded for 30K/year for two years) in that four investigators have already received either a K award or a DP3 award and a fifth awardee has secured a RO1. We believe our P&F program, owing to the ability to leverage institutional matching funds and the ability to extend over two years, has been one of the most successful aspects of the Center. Our enrichment program is extensive and includes collaborations with multiple entities across campus. We propose to build on the excellence of the past five years by maintaining continuity in our core structure and leadership while introducing a new core (Behavioral Intervention Technologies and Services Core) and leader (Chandra Osborn, Ph.D.) to reflect the expanding research base that utilizes technology for behavioral interventions. We maintain a focus on health disparities through our long standing relationship with Meharry Medical College and build on that foundation by introducing a new leader (Consuelo Wilkins, M.D.) to lead our enrichment core. Dr. Wilkins leads the Meharry-Vanderbilt Alliance (https://medschool.vanderbilt.edu/meharry- vanderbilt/) which explicity promotes collaboration between our two institutions to promote clinical and community-engaged collaboration, education and research. These additions build on our theme of reducing health disparities while expanding on our efforts to advance knowledge in behavioral intervention technologies.