Core D: Histology and Imaging Core

北卡罗来纳大学胃肠道生物与疾病中心(CGIBD)的总体使命是促进 加强消化系统疾病的多学科研究。这项任务部分是通过以下方式完成的 为中心成员提供实验室服务、培训和技术支持的核心实验室。这个 组织学核心通过为成员提供基本的组织病理学服务来支持CGIBD的使命 进行消化系统疾病研究。本中心提供的服务包括在 计划阶段的实验，分析人和小鼠的肠道、肝脏、胰腺和其他与胃肠道相关的 组织标本作组织学和免疫组织化学检查。我们还提供了四种荧光材料 显微镜；蔡司AXIO成像仪、蔡司AXIO Primo星形显微镜和奥林巴斯IX71和IX81倒置 荧光显微镜。此外，核心还提供数字幻灯片扫描和图像分析服务 与北卡罗来纳大学转化性病理学实验室(TPL；https://tpl.med.unc.edu/l)合作提供一项新服务 是为用户提供亮场和荧光活细胞成像。第三方物流的主要目标是将实验室 及时发现临床护理领域的研究发现。与第三方物流的合作伙伴关系是 有益的，因为它允许CGIBD组织核心向中心提供尖端的数字成像服务 会员。 核心人员包括一名教务主任、一名组织技术员和研究助理 监督幻灯片数字化过程。核心主任在组织学和癌症方面拥有广泛的专业知识 生物标记物和监督核心的管理。组织技术员有超过15年的经验 组织病理学，负责组织分析和数字处理的样品准备和处理 成像是按服务收费的。她有两名研究助理帮助她完成这些职责。就像可能的那样 从核心使用报告来看，核心被中心成员和北卡罗来纳大学的其他研究人员大量使用

The overall mission ofthe UNC Center for Gastrointestinal Biology and Disease (CGIBD) is to promote and enhance multidisciplinary research in digestive diseases. This mission is accomplished in part, through core laboratories that provide laboratory services, training, and technical support to center members. The Histology Core supports CGIBD's mission by providing essential histopathological services to members conducting digestive diseases research. The services provided by the Core include consultation during the planning phase of experiments, analysis of human and mouse intestine, liver, pancreas, and other GI related tissue specimens for histology and immunohistochemistry. We also provide access to four fluorescent microscopes; a Zeiss AXio Imager, a Zeiss AXio Primo Star Microscope and Olympus IX71 and IX81 inverted fluorescence microscopes. In addition, the Core provides digital slide scanning and image analysis services in partnership with the UNC Translational Pathology Laboratory (TPL; https://tpl.med.unc.edu/l A new service is to provide brightfield and fluorescent live cell imaging to users. The main goal of TPL is to take laboratory research discoveries into the realm of clinical care in a timely manner. The partnership wdth the TPL is beneficial because it allows the CGIBD Histology Core to provide cutting edge digital imaging services to Center members. The Core personnel include a faculty director, a histotechnician, and research assistants who vsdll oversee the slide digitization process. The Core Director has broad expertise in histology and cancer biomarkers and oversees the administration ofthe Core. The histotechnician has over 15 years experience in histopathology and is responsible for sample preparation and processing for histological analysis and digital imaging on a fee for service basis. She has two research assistants who help her with these duties. As can be seen from the Core Use report, the Core is heavily utilized by Center members and other researchers at UNC