2016 DNA Damage, Mutation and Cancer Gordon Research Conference & Gordon Research Seminar

 描述（由申请人提供）：2016年戈登DNA损伤，突变和癌症会议将介绍负责识别和处理环境DNA损伤以及固有不稳定DNA序列的分子机制的前沿研究。多种生化机制识别DNA损伤或难以解开DNA结构，最终产生解决途径的选择。竞争和合作的DNA修复机制是内在基因组稳定性与健康和疾病不稳定性之间微妙平衡的核心。了解这些机制对于开发下一代抗癌疗法至关重要，这些疗法将利用正常细胞和肿瘤细胞之间的基因型差异。 这些前沿科学主题将在会议的九次会议上讨论，暂定标题为：基因组固有的稳定性和不稳定性;基因组的薄弱环节;环境基因组损害;基因组不稳定性中的RNA-DNA相互作用;氧化DNA损害和碱基切除修复;对复制受阻的突变反应;检查点和链断裂修复; FoSTeS、Kataegis和Chromothripsis;以及基于癌症基因组学的新兴化疗。 我们邀请的演讲者代表了各种科学学科，包括分子遗传学，生物化学， 结构生物学和分子肿瘤学。会议将汇集具有广泛背景和兴趣的多元化研究人员，促进新的研究和合作。它将为年轻的科学家和研究生提供机会，以海报的形式展示他们的工作，并与该领域的领导人交流思想，以及参加为期两天的戈登研究研讨会的可能性。一些海报主持人将被选为最后打破简短的会谈。 我们预计，本次会议期间的激烈科学互动将以许多重要的方式影响癌症研究，并导致建立富有成效的多学科研究合作。2016年DNA损伤、突变和癌症戈登研究会议将于2016年3月13日至18日在加州文图拉的文图拉海滩万豪酒店举行。

 DESCRIPTION (provided by applicant): The 2016 Gordon Conference on DNA Damage, Mutation & Cancer will present cutting-edge research on the molecular mechanisms responsible for the recognition and processing of environmental DNA damage as well as inherently unstable DNA sequences. Multiple biochemical mechanisms recognize DNA lesions or difficult to unravel DNA structures, ultimately yielding a choice of pathways for resolution. Competing and collaborating DNA repair mechanisms are at the heart of a delicate balance between inherent genomic stability and instability in health and disease. Understanding these mechanisms is crucial for developing next generation anti-cancer therapies that will take advantage of genotypic differences between normal cells and tumor cells. These front-line scientific topics will be discussed in the conference's nine sessions provisionally entitled: Inherent Genomic Stability and Instability; Genome Weak Links; Environmental Genomic Damage; RNA-DNA Interplay in Genome Instability; Oxidative DNA damage and Base Excision Repair; Mutagenesis in Response to Arrested Replication; Checkpoints and Strand-Break Repair; FoSTeS, Kataegis and Chromothripsis; and Emerging Chemotherapies Based on Cancer Genomics. Our invited speakers represent a variety of scientific disciplines, including molecular genetics, biochemistry, structural biology and molecular oncology. The Conference will bring together a diverse group of researchers with broad backgrounds and interests stimulating new research and collaborations. It will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field, as well as the possibility to attend the inaugural two-day Gordon Research Seminar, which precede the Conference. Some poster presenters will be selected for late-breaking short talks. We anticipate that intense scientific interactions during this conference will impact cancer research in many significant ways and result in establishing productive multi-disciplinary research collaborations. The 2016 DNA Damage, Mutation & Cancer Gordon Research Conference will be held at the Ventura Beach Marriott, in Ventura, California March 13 - 18, 2016.