Adherence Connection for Counseling, Education, and Support (ACCESS): A Proof of Concept Study

 描述（由申请人提供）：这个指导以患者为导向的研究职业发展奖-（K23）旨在为候选人的职业过渡到独立的护士科学家提供先进的知识，技能和经验。她的长期目标是成为设计，实施和评估技术支持的行为干预措施的领先护士科学家，这些干预措施旨在改善人类免疫缺陷病毒（HIV）感染者，少数民族青少年和年轻人的疾病自我管理（即药物依从性，保留护理）。在儿科艾滋病毒护理和完成NIH资助的博士前和博士后跨学科研究培训的广泛背景下，候选人已经开始开发这一目标所需的知识基础和技能。该奖项详细介绍了为期3年的指导职业发展范围，通过该范围，她将为未来的研究工作奠定基础。具体而言，该提案的目标是：1）在专家研究人员的跨学科团队的指导下进行一个新的研究项目; 2）通过第一手经验，与导师的教学互动和研究生水平的课程，获得健康信息学的专业知识，用于实施技术支持的行为干预，健康差异和先进的定性和混合方法设计和分析; 3）通过这项研究和参加国家和国际会议，在纽约大学和其他地方建立同事和合作者网络; 4）根据该奖项期间的技能和发现，准备并提交联邦研究补助金（R-21）。具体的研究项目，通过它，她将实现这些目标是一个概念研究，坚持连接咨询，教育和支持（访问）的证明，并解决了艾滋病毒感染的青少年和年轻人坚持抗逆转录病毒治疗的挑战。提出了一种混合方法设计，具体目标是：1）表征通过使用智能手机的远程视频会议提供的同伴主导的mHealth认知行为干预的可行性和可接受性; 2）获得ACCESS对HIV病毒学结果和自我报告的ART依从性、关于抗逆转录病毒治疗的信念和知识、依从性自我效能的生物行为影响的初步估计，和医疗保健利用率（保留在艾滋病毒护理中）。总之，ACCESS依从性干预与国家护理研究所（NINR）呼吁开发新的干预措施，为患者提供个性化护理和实时健康信息是一致的。

 DESCRIPTION (provided by applicant): This Mentored Patient-Oriented Research Career Development Award - (K23) seeks to provide the advanced knowledge, skills, and experience for the candidate's career transition to an independent nurse scientist. Her long term goal is to become a leading nurse scientist in designing, implementing, and evaluating technology supported behavioral interventions targeted for improved disease self-management (i.e. medication adherence, retention in care) among human immunodeficiency virus (HIV)-infected, ethnic minority adolescents and young adults. With an extensive background in pediatric HIV nursing and completed NIH funded pre and post-doctoral interdisciplinary research traineeships, the candidate has begun to develop the knowledge-base and skills necessary for this goal. This award details a 3-year scope of mentored career development through which she will gain the foundation for future research endeavors. Specifically, the goals of this proposal are to: 1) conduct a novel research project under the mentorship of an interdisciplinary team of expert researchers; 2) acquire expertise in health informatics for implementation of technology supported behavioral interventions, health disparities, and advanced qualitative and mixed methods design and analysis through firsthand experience, didactic interactions with mentors, and graduate level coursework; 3) build a network of colleagues and collaborators within New York University and elsewhere through this research and participation at national and international meetings; and 4) prepare and submit a federal research grant (R-21) based upon the skills and findings from this award period. The specific research project through which she will accomplish these goals is a proof of concept study, Adherence Connection for Counseling, Education, and Support (ACCESS), and addresses the challenge of adherence to antiretroviral treatment among HIV-infected adolescents and young adults. A mixed method design is proposed and the specific aims are to: 1) Characterize the feasibility and acceptability of a peer led, mHealth cognitive behavioral intervention delivered via remote videoconferencing using smartphones; 2) Obtain initial estimates of the biobehavioral impact of ACCESS on HIV virologic outcomes and self-reported ART adherence, beliefs and knowledge about antiretroviral treatment, adherence self-efficacy, and healthcare utilization (retention in HIV care). In summary, the ACCESS adherence intervention is consistent with the National Institute of Nursing Research (NINR) call for the development of novel interventions to deliver personalized care and real-time health information for patients.