Impact of Drug Use Treatment on HIV Risk Behaviors: An Integrative Data Analysis

描述（由申请人提供）：拟议的研究将使用综合数据分析（IDA）方法检查现有的行为药物滥用治疗作为艾滋病毒预防策略的有效程度。IDA允许对多个原始数据集进行分析，这些数据集使用协调的变量汇集成一个数据集。这项研究将汇集通过国家药物滥用研究所（NIDA）临床试验网络（CTN）进行的行为药物滥用治疗的数据。具体而言，本研究将：(1)结合15个单独的NIDA CTN行为药物滥用治疗试验（N=6,896个独特参与者）的数据，创建一个具有协调变量和相应协调数据代码本的汇总数据se；(2)使用统一变量的汇总数据集评估NIDA CTN行为药物滥用治疗减少艾滋病毒传播风险行为的程度，这些行为定义为注射吸毒、共用针头和性风险行为（如无保护的性交、性交易）；(3)研究NIDA CTN行为药物滥用治疗降低HIV传播风险行为有效性的潜在调节因子。将检查的核心调节因素是抽样特征（例如，年龄、性别、种族/民族、基线药物使用行为参与）和研究设计特征（例如，纳入艾滋病毒风险降低干预内容、干预方式、干预时间）。拟议研究的结果将提供必要的信息，指导未来干预措施的制定、调整和传播，以减少和预防药物滥用和艾滋病毒。

DESCRIPTION (provided by applicant): The proposed study will examine the extent to which extant behavioral drug abuse treatments are effective as an HIV prevention strategy using an integrative data analysis (IDA) approach. IDA allows for analysis of multiple original data sets that have been pooled into one using harmonized variables. This research will pool data from behavioral drug abuse treatments conducted through the National Institute on Drug Abuse's (NIDA) Clinical Trials Network (CTN). Specifically, this research will: (1) create a pooled data se with harmonized variables and corresponding harmonized data codebook combining data from 15 individual NIDA CTN behavioral drug abuse treatment trials (N=6,896 unique participants); (2) evaluate the extent to which NIDA CTN behavioral drug abuse treatments reduce HIV transmission risk behaviors defined as injection drug use, needle sharing, and sexual risk behaviors (e.g., unprotected sexual intercourse, trading sex for drugs) using the pooled data set with harmonized variables; and (3) examine potential moderators of the effectiveness of NIDA CTN behavioral drug abuse treatments to reduce HIV transmission risk behaviors. Core moderating factors that will be examined are sampling characteristics (e.g., age, gender, race/ethnicity, baseline drug use behavior engagement) and study design features (e.g., inclusion of HIV risk reduction intervention content, intervention modality, intervention length). Results from the proposed research will provide requisite information to guide the development, adaptation, and dissemination of future interventions to reduce and prevent both drug abuse and HIV.