The Development of a Low-Cost, Quantitative Skin Imaging Camera

摘要 慢性伤口的管理是当今老龄化人口的负担。专业的伤口护理 需要监测和跟踪皮肤健康。数码摄影的进步使其成为 有效和经济的监测和治疗选择。然而，即使有最好的 在这种情况下，照片通常提供临床医生将 解释以评估生理组织健康。光学成像的最新进展 方法和装置提供了对组织结构进行定量表征的能力 和生化状态。调制成像（MI），也称为空间频率域 成像（SFDI）采用多光谱，图案化照明，以非侵入性地获得 生物组织的表面下图像。这项研究计划的主要目标是建立和 验证将MI技术引入床旁（Point-of-Care，简称POS）应用的手持系统。这 “PoC-MI”器件将大大简化系统复杂性和尺寸，同时主要利用 现成的消费级组件。基于第一阶段的研究成果，我们 我已经确定了硬件和算法，使我们能够建立一个PoC-MI设备在较低的 成本（BOM减少约10倍），重量更轻（约10倍），采集速度更快（0.1 ms， 比以前的技术版本快约100- 1000倍）。在第二阶段的提案中， 我们建议设计和制造一个低成本的，手持平板电脑的形状因子，定量皮肤， 在组织模拟体模上仔细评估装置性能的成像照相机 在完善的临床前和临床模型中进行性能验证。的结果 这项拨款将是第一个提供定量生物化学信息的生物化学信息系统， 将皮肤制成片剂形状因子，使得能够广泛应用于慢性 伤口

Abstract Management of chronic wounds are a burden in today’s aging population. Expert wound care is needed to monitor and track skin health. Advances in digital photography have made it an efficient and economic option for surveillance and treatment. However, even with the best of circumstances, photographs typically provide qualitative color information that the clinician will interpret to assess physiological tissue health. Recent advancements in optical imaging methods and devices offer the ability to perform quantitative characterization of tissue structure and biochemical status. Modulated Imaging (MI), also known as Spatial Frequency Domain Imaging (SFDI) employs multispectral, patterned illumination to non-invasively obtain subsurface images of biological tissue. The broad goal of this research proposal is to build and validate a handheld system that brings MI technology to point-of-care (PoC) applications. This “PoC-MI” device will dramatically simplify system complexity and size, while utilizing primarily off-the-shelf consumer-grade components. Based on research accomplishments in Phase I, we have identified hardware and algorithms that will enable us to build a PoC-MI device at lower cost (~10x BOM reduction), lighter weight (~10x lighter), and with faster acquisition (0.1 ms, ~100-1000x faster) compared to previous revisions of the technology. In this Phase II proposal, we propose to design and fabricate a low-cost, hand-held tablet form factor, quantitative skin imaging camera with careful assessment of device performance on tissue-simulating phantoms and performance validation in well-established pre-clinical and clinical models. The results of this grant will be the first PoC MI system that provides quantitative biochemical information of the skin into a tablet form factor, enabling wide applicability in clinical management of chronic wounds.