Effect of low-intensity versus moderate-intensity endurance exercise on physical functioning among breast cancer survivors: a randomized controlled trial

 描述(由申请人提供)：妇女乳腺癌早期诊断和治疗的改进导致了存活率的提高。然而，存活率增加的一个意想不到的后果是，更多的女性生活在与癌症治疗相关的负面后遗症中，包括身体功能下降。运动在消除这些后遗症方面是有益的，但坚持运动指南仍然是一个挑战。由于大多数乳腺癌幸存者都是中老年人，提高锻炼参与度和坚持性的替代方案可能是提供低强度锻炼计划。这项研究的总体目的是评估低强度和中等强度耐力锻炼计划对乳腺癌幸存者身体功能的影响。据推测，低强度运动计划的参与者将表现出与中等强度运动计划参与者相似的身体功能。计划行为理论将作为干预的框架。一个方便的样本，142名波多黎各居民，年龄在50岁或以上，被诊断为单侧乳腺癌，从0期到II期，她们接受了乳腺癌的手术治疗，无论有没有辅助治疗，将被随机分配到低强度或中等强度耐力干预组。这两种干预措施都将在家中进行，持续时间为6个月，并由物理治疗师提供。对小组分配视而不见的评估员将在基线和干预结束时对参与者进行评估。主要结果指标将包括身体功能和与健康相关的生活质量。

 DESCRIPTION (provided by applicant): Improvements in early diagnosis and treatment for breast cancer in women have resulted in increased survivorship. An unintended consequence of increased survival, however, is that more women are living with the negative sequelae associated with cancer treatment, including decreased physical function. Exercise has been beneficial in arresting these sequelae, but adherence to exercise guidelines continues to be a challenge. As most breast cancer survivors are middle-aged and older, an alternative to enhance exercise engagement and adherence might be providing a low intensity exercise program. The overall purpose of this study is to assess the impact of a low intensity versus moderate intensity endurance exercise program on physical functioning on breast cancer survivors. It is hypothesized that participants of the low intensity exercise program will demonstrate similar physical functioning as participants in the moderate intensity exercise program. The Theory of Planned Behavior will serve as framework for the intervention. A convenience sample of 142 women, residents of Puerto Rico, age 50 or older, with a diagnosis of unilateral breast cancer, stage 0 thru II, who have received surgical treatment for breast cancer, with or without adjuvant therapy, will be randomly assigned to a low intensity or moderate intensity endurance intervention. Both interventions will be home-based, have a duration of 6 months, and be provided by physical therapists. An evaluator blinded to group assignment will assess participants at baseline and at completion of the intervention. Primary outcome measures will consist of physical functioning, and health-related quality of life.