Biomedical Informatics and Statistics Core

项目摘要 我们建议建立一个联盟，研究“尼日利亚艾滋病毒相关癌症的表观基因组生物标志物”。 我们的研究重点和核心服务发展计划已被我们的尼日利亚合作伙伴优先考虑， 乔斯大学（UniJos），高原州，尼日利亚位于该国的中心和拉各斯大学 （UniLag），位于人口稠密的西南部的拉各斯州。我们专注于HIV相关的表观遗传学 肝细胞癌（HCC）和宫颈癌是合理的，我们广泛的合作研究历史 病毒性疾病包括HIV、人乳头瘤病毒、B型肝炎和C型肝炎病毒。西北大学和 马约医学院将作为高收入的美国合作机构，这是有道理的长期 与尼日利亚机构的研究和研究培训合作的历史，加上其在以下方面的专门知识： 全球健康和充足的补充资源。生物医学信息学的具体目标和 统计核心（BISC）是：1。加强现有的临床系统（艾滋病毒诊所电子数据库和癌症 登记处），以开发高质量的电子临床数据收集艾滋病毒相关癌症的门诊 UniJos和UniLag的住院系统，2.发展生物医学信息学和统计学合作 团队专注于为尼日利亚的艾滋病毒相关癌症遗传学研究提供核心服务;提供 监督和支持项目1（HCC）和项目2（宫颈癌）的信息学和统计需求 在U 54下在该基础信息系统委员会下，将协调电子数据收集和管理能力， 癌症研究信息系统（CRIS）CRIS将包括以下几个方面：（1）数据 收集，（2）分发调查，以进行需求评估和社区参与，（3）交流， （4）财务/赠款管理，（5）数据管理和质量保证，（6） 临床数据和研究生物样本库样本，（7）跟踪/遵守研究提案，以及 (8)BISC服务的跟踪和成果。还将开发下列BISC服务： 数据整合和管理、计算设施和生物统计咨询。的总目标 BISC将支持和促进项目1（HCC）和2（宫颈）中提出的研究，提供设施， 对于职业提升核心（CEC）下的培训活动，协调研究服务与 病理学和基因组学核心（PGC），建立基础设施和研究管理与行政 核心（AC）。

Project Summary We propose to establish a Consortium to study “Epigenomic Biomarkers of HIV-Associated Cancers in Nigeria.” Our research focus and core services development plan has been prioritized by our Nigerian partners at University of Jos (UniJos), Plateau State, Nigeria located in the center of the country and University of Lagos (UniLag), Lagos State in the densely populated southwest. Our focus on the epigenetics of HIV-associated hepatocellular carcinoma (HCC) and cervical cancer is justified by our extensive collaborative research history in viral diseases including HIV, human papilloma virus, hepatitis B and C viruses. Northwestern University and Mayo Medical School will serve as the high-income American partner institutions which is justified by the long history of research and research training collaboration with the Nigerian institutions coupled with its expertise in global health and ample complementary resources. The specific aims of the Biomedical Informatics and Statistics Core (BISC) are: 1. enhance the existing clinical systems (HIV clinic electronic databases and cancer registries) to develop high-quality electronic clinical data collection on HIV-associated cancers across outpatient and inpatient systems at UniJos and UniLag, 2. develop a collaborative biomedical informatics and statistics team focused on providing core services for HIV-associated cancer genetics research in Nigeria, and 3. provide oversight and support for the informatics and statistical needs of Projects 1 (HCC) and 2 (cervical) proposed under this U54. Under this BISC, electronic data collection and management capabilities will be coordinated into a single Cancer Research Informatics System (CRIS). CRIS will include the following aspects: (1) data collection, (2) survey distribution for needs assessments and community engagement, (3) communication and BISC coordination, (4) financial/grants management, (5) data management and quality assurance, (6) linkage of clinical data and research biospecimen repository samples, (7) tracking/compliance of research proposals, and (8) tracking and outcomes of BISC services. The following BISC services will also be developed: centralized data integration and management, computational facilities and biostatistical consultations. The overall goal of the BISC will be to support and facilitate research proposed in Projects 1 (HCC) and 2 (cervical), provide facilities for training activities under the Career Enhancement Core (CEC), coordination of research services with the Pathology and Genomics Core (PGC), build infrastructure and research management with the Administrative Core (AC).