Statistical methods for estimating relative intensity physical activity and its association with cardiometabolic disease

项目摘要 强度是一个关键因素时，考虑的剂量的体力活动（PA）所需的实现特定的健康 和健身效果。需氧PA的强度可以根据绝对强度或 相对强度绝对强度是指进行一项活动所需的能量或功， 考虑到个人的运动能力。相对强度考虑或调整为 人的运动能力。对于许多肥胖和/或不健康的成年人来说，可能不可能达到中度- 由于他们的运动能力低，在绝对量表上测量的强度PA。然而，这些成年人可能 能够在相对规模上进行中等强度的PA。关于剂量的证据有限 相对强度PA必要的促进和维持健康。解决这个问题具有重要意义。 个人应如何监测PA强度，医生应如何开PA处方， 以及如何设计运动干预措施。证据数量有限的一个原因是， 相对强度PA与健康之间的关系是相对强度难以测量。 因此，几乎所有的大型前瞻性观察性研究都是在绝对尺度上测量PA强度。 可穿戴监测器（加速度计）广泛用于流行病学和临床研究， 捕获PA的客观估计值，而没有很大的参与者负担。这些装置将身体运动 并且有几个公开的用于分类PA的阈值或分界点 基于计数的绝对标度上的强度。年轻人的冠状动脉风险发展 （CARDIA）研究是一项正在进行的队列研究，共有5，115名18 - 30岁的非洲裔美国人和白色男性和女性参与 处于1985 - 1986年的基线。2005 - 2006年，对2，760名患者进行了辅助性心脏健康研究， 年龄在38至50岁之间的参与者在标准化分级运动跑步机测试中佩戴加速度计， 一周的正常活动。参与者随后在2010 - 2011年和2015 - 2016年重新审查， 测量心血管疾病危险因素的发展。使用CARDIA研究的数据，我们将 开发和验证使用加速度计客观测量相对强度PA的统计方法。 我们的具体目标是：1）发展计算相对强度PA加速度计切割的统计方法， 点，并将这些方法应用于CARDIA运动平板试验的数据; 2）使用CARDIA数据， 估计相对强度PA与心脏代谢疾病发展之间的关系， 与绝对强度PA相比。3)调查我们的方法的普遍性，以更多的翻译 校准设置。

PROJECT SUMMARY Intensity is a key factor when considering the dose of physical activity (PA) required to achieve specific health and fitness outcomes. The intensity of aerobic PA can be defined either in terms of absolute intensity or relative intensity. Absolute intensity refers to the energy or work required to perform an activity and does not take into account the exercise capacity of the individual. Relative intensity takes into account or adjusts for a person's exercise capacity. For many obese and/or unfit adults, it may not be possible to achieve moderate- intensity PA as measured on an absolute scale due to their low exercise capacity. However, these adults may be able to perform moderate-intensity PA on a relative scale. There is limited evidence regarding the dose of relative intensity PA necessary to promote and maintain health. Addressing this question has important implications regarding how individuals should monitor their PA intensity, how physicians should prescribe PA, and how exercise interventions should be designed. One reason for the limited amount of evidence on the relationship between relative intensity PA and health is the fact that it is difficult to measure relative intensity. As a result, nearly all large prospective observational studies measure PA intensity on an absolute scale. Wearable monitors (accelerometers) are widely used in both epidemiological and clinical research studies for capturing objective estimates of PA without a large participant burden. These devices convert body movement into derived accelerometer “counts” and there are several published thresholds or cut-points for classifying PA intensity on an absolute scale based on counts. The Coronary Artery Risk Development in Young Adults (CARDIA) study is an ongoing cohort study of 5,115 African American and White men and women aged 18-30 at baseline in 1985-1986. In 2005-2006, an ancillary CARDIA Fitness Study was performed on 2,760 participants aged 38 to 50 who wore accelerometers during a standardized graded exercise treadmill test and for 1 week of normal activity. Participants were subsequently re-examined in 2010-2011 and 2015-2016 to measure the development of cardiovascular disease risk factors. Using data from the CARDIA study, we will develop and validate statistical methods for objectively measuring relative intensity PA using accelerometry. Our specific aims are: 1) Develop statistical methods for calculating relative-intensity PA accelerometer cut- points and apply these methods to data from the CARDIA exercise treadmill test; 2) Use the CARDIA data to estimate the relationship between relative-intensity PA and the development of cardiometabolic disease as compared to absolute-intensity PA. 3) Investigate the generalizability of our methodology to more translational calibration settings.