2017 Grover Conference

项目摘要 提议的2017年格罗弗会议“血管病理学前沿的内皮细胞， 肺血管疾病的治疗靶向”将汇集成熟的研究人员和初级 科学家（初级教师，研究员和学生）在一个互动论坛中，肺的多种作用， 内皮在健康和疾病将讨论的目标，以确定主要的病理机制 并确定未来的治疗策略，以应对无法治愈的肺 与肺循环严重功能障碍相关的疾病，如PAH、COPD和ARDS。那里 将有34位已确认的国家和国际演讲者介绍最新的研究结果和新概念。 将特别强调血管内皮在肺部疾病的进展和逆转中的作用， 反映在以下主要讨论议题：1）表型多样性和血管的作用 内皮在肺损伤和修复的启动中的作用; 2）肺循环的多方面作用， 特别地，血管内皮在肺疾病（ALI/ARDS，PH， COPD、ILD和CF）; 3）肺内皮微环境和宏观环境的作用以及肺内皮细胞之间的通讯 肺动脉高压和急性呼吸窘迫综合征中血管内皮细胞的不同类型; 对肺动脉高压和急性呼吸窘迫综合征发病机制的影响; 5）对肺动脉高压和急性呼吸窘迫综合征中内皮细胞受累的更广泛研究 其他肺部疾病的循环相关异常; 6）未来以内皮为中心的研究的制定 治疗肺部疾病的指导。这次会议的必要性很高，因为没有其他会议与此有关。 在北美举行的科学焦点。我们期待研究人员（MD和PhD）的参与， 对肺动脉高压、ARDS、COPD、间质性肺疾病感兴趣的研究型临床医生 心力衰竭、先天性心脏病、发育生物学以及基础和转化研究人员 对细胞、分子生物学与心肺疾病的交叉感兴趣。 为了加强年轻科学家的参与，该计划包括每天几次简短的会谈， 精选最佳摘要除了重点讲座外，下午还将举办海报展示会， 允许学生，研究员和初级教师在非正式的环境中展示他们的研究。以促进 初级研究者和资深研究者之间的互动，将在海报发布前举行圆桌讨论会 会议-将指派高级调查员主持这些会议。这一过程将使年轻人 研究人员专门花时间与会议组织者，会议主席和任何NIH 代表出席。每一位受邀演讲者都必须提交一份手稿， 主题和适当的相关信息，以杂志肺循环，领先的杂志在肺 关注肺部病变的血管方面。

PROJECT SUMMARY The proposed 2017 Grover Conference "Endothelium at the frontline of Vascular Pathobiology and Therapeutic Targeting in Lung Vascular Disease" will bring together established investigators and junior scientists (junior faculty, fellows, and students) in an interactive forum in which multiple roles of pulmonary endothelium in health and disease will be discussed with the goal to determine major pathologic mechanisms triggered by disturbed endothelium and define future therapeutic strategies to confront un-curable lung diseases associated with major dysfunctions of pulmonary circulation such as PAH, COPD and ARDS. There will be 34 confirmed national and international speakers presenting most recent findings and new concepts. Specific emphasis will be made on vascular endothelium in progression and reversal of lung disease and reflected in the following main discussion topics: 1) Phenotypic diversity and the role of the vascular endothelium in the initiation of lung injury and repair; 2) Multi-faceted role of the pulmonary circulation and specifically, the vascular endothelium in the pathogenesis and modulation of lung diseases (ALI/ARDS, PH, COPD, ILD and CF); 3) Role of lung endothelial micro- and macro-environment and communication between different vascular cell types in PAH and ARDS; 4) Metabolic dysregulation in vascular endothelium and its impact in pathogenesis of PAH and ARDS; 5) Broader investigation of endothelial involvement in pulmonary circulation-related abnormalities in other lung diseases; 6) Formulation of future endothelial-centric research directions to treat lung disease. The need for this meeting is high, since there are no other meetings with this scientific focus held in North America. We anticipate participation by researchers (both MD and PhD) and research-oriented clinicians interested in pulmonary hypertension, ARDS, COPD, interstitial lung disease right heart failure, congenital heart disease, developmental biology as well as basic and translational researchers interested in the intersection of cell, molecular biology with cardiopulmonary diseases. To enhance participation of junior scientists, the program includes several short talks each day based on selected best abstracts. In addition to the key lectures, there will be poster sessions in the afternoons to allow students, fellows and junior faculty to present their research in an informal setting. To facilitate interactions between junior and established investigators, roundtable discussions will be held prior to poster sessions—senior investigators will be assigned to lead these sessions. This process will allow junior investigators dedicated time to meet with the conference organizers, session chairs, and any NIH representatives in attendance. Each invited speaker will be required to submit a manuscript describing their topic and appropriate related information to the journal Pulmonary Circulation, the leading journal in pulmonary community focused on vascular aspects of lung pathologies.