Biostatistics

生物统计学核心的目的是与SPORE研究人员就其研究项目进行合作 并监督临床试验的进行。具体而言，生物统计学核心将开发统计 设计、制定统计分析计划、执行数据采集、开发数据库、存档数据， 制定临床研究表格，对涉及人类受试者的临床试验进行数据监测， 数据分析和解释，并在手稿，摘要和演示文稿的发展援助。 这一目标将通过以下具体目标来实现：1）与SPORE合作 研究者对研究设计进行研究，以开发具有适当统计操作特征的项目2） 为每个SPORE项目提供统计分析计划3）对项目结果进行统计分析 按照统计分析计划中的规定，并与SPORE研究者合作进行解读 4）监督SPORE临床研究项目的开展，以确保 患者安全和项目的科学完整性5）与SPORE研究人员合作， 数据分析结果的解释，并帮助手稿，摘要和 介绍。 一个由两名教师和两名硕士培训的生物统计学家组成的团队已经组装，以满足 项目的统计方法和分析需要，包括项目设计和分析方面的专门知识 高维数据和临床试验。该小组将确保设计和分析是适当的 以满足项目的目标，这对SPORE的成功至关重要。生物统计学核心将 导演：Jane Meza博士另外还有方宇博士（专注于高维度 数据分析），Lynette Smith M.S.（经过硕士培训的生物统计学家，专门研究高维数据 分析）和Robin High M.A.（生物统计学硕士）。

The purpose of the Biostatistics Core is to collaborate with SPORE investigators on their research projects and to monitor the conduct of the clinical trials. Specifically, the Biostatistics Core will develop statistical designs, develop statistical analysis plans, perform data acquisition, develop databases, archive data, develop clinical research forms, perform data monitoring for clinical trials involving human subjects, perform data analysis and interpretation and aid in the development of manuscripts, abstracts and presentations. This purpose will be accomplished through the following specific aims: 1) Collaborate with SPORE investigators on study design to develop projects with appropriate statistical operating characteristics 2) Provide a statistical analysis plan for each SPORE project 3) Perform statistical analyses of project results as specified in the statistical analysis plan and collaborate with SPORE investigators on the interpretation and reporting of research findings 4) Monitor the conduct of SPORE clinical research projects to ensure patient safety and the scientific integrity of the projects 5) Collaborate with SPORE investigators on interpretation of data analysis results and aid in the development of manuscripts, abstracts and presentations. A team of two faculty and two Masters-trained biostatisticians has been assembled to meet the range of statistical methodological and analytical needs of the projects, including expertise in design and analysis of high-dimensional data and clinical trials. This team will ensure that the design and analyses are appropriate to meet the aims of the projects, which is essential to the success of the SPORE. The Biostatistics Core will be directed by Jane Meza Ph.D. and additionally staffed by Fang Yu Ph.D. (specializing in high-dimensional data analysis), Lynette Smith M.S. (Masters-trained biostatistician specializing in high-dimensional data analysis) and Robin High M.A. (Masters-trained biostatistician).