The Effects of Spironolactone on Inflammation in a Rodent Model of Pulmonary Arterial Hypertension

自2015年12月动物护理和使用委员会批准本方案以来，我们一直在开发啮齿动物超声心动图和心导管插入术的必要技术技能。研究的第1部分，确定我们小组SU-5416/缺氧/常氧模型的重现性，以及必要的导管插入术和超声心动图程序的开发，于2016年8月开始。这项研究目前正在进行中。我们的计划是继续进行第2部分，到2017年初确定螺内酯与依普利酮在该模型中的作用。

Since the time of Animal Care and Use Committee approval of this protocol in December 2015, we have been developing the necessary technical skills in rodent echocardiography and cardiac catheterization. Part 1 of the study, determining the reproducibility of the SU-5416/hypoxia/normoxia model by our group, as well as the development of the necessary catheterization and echocardiography procedures, commenced in August 2016. The study is currently ongoing. Our plans are to continue on to Part 2, determining the effects of spironolactone versus eplerenone in this model by early 2017.