Deciphering the role of Notch signaling in zebrafish heart regeneration

 描述（由申请人提供）：刺激人类心肌再生的新型治疗策略将显著改善心脏病发作患者的临床结局。与人类不同，成年斑马鱼在受伤后会自然再生心肌。我们的实验室最近发现，Notch信号通路在斑马鱼心脏损伤后被激活，并且是刺激新心肌生长所必需的。本申请的目标是获得Notch如何刺激鱼类心脏再生的新机制见解，长期目标是为重新定向或重新利用激活的Notch以获得人类临床益处提供新的治疗策略。

 DESCRIPTION (provided by applicant): Novel therapeutic strategies for stimulating regeneration of human heart muscle would significantly improve clinical outcomes for patients experiencing a heart attack. In contrast to humans, adult zebrafish naturally regenerate their heart muscle following injury. Our lab recently discovered that the Notch signaling pathway becomes activated following cardiac injury in zebrafish and is required for stimulating growth of new cardiac muscle. The goal of this application is to gain new mechanistic insight into how Notch stimulates heart regeneration in fish with the long-term goal of informing new therapeutic strategies for redirecting or repurposing activated Notch for clinical benefit in humans.