Institutional Career Development Core Supplement

摘要 加州大学旧金山分校临床与翻译科学研究所KL2学者计划的理论基础和基本目标 该计划旨在培养、指导和装备下一代杰出和多样化的初级教员 具有方法论、分析、领导力和团队科学技能的调查人员 变革性的临床和转化性研究。该计划的校友，作为个人和成员 多学科团队，为终身健康科学研究做出了杰出贡献。 拟议的职业发展计划是临床科室和研究单位的主要资源。 并且不会与加州大学旧金山分校现有的培训项目重复。在继续成功的 KL2计划，拥有临床和方法学研究、多点研究和试验方面的核心教员专业知识，以及 作为弱势群体，该计划为加州大学旧金山分校的教师提供了一种经过验证的重要资源 医学、护理学、牙科和药剂学。在拟议的资助期内，该计划将利用加州大学旧金山分校的 与基础科学家、生物制药研究人员和行业的独特优势和合作伙伴关系 创新者将其学者定位为继续推进临床和翻译科学领域， 以下提议的目标：目标1.招募一批专业和种族多元化的加州大学旧金山分校 初级教师KL2奖学金，并在他们迈向研究的过程中为他们提供长达3年的支持 独立，获得NIH K和R个人奖项；目标2.扩大和加强培训和辅导 临床和转化性研究的前沿，与其他CTSI计划合作，强调 尖端研究方法；目标2a。教育、培训和指导KL2学者以充分利用 技术驱动的研究方法；目标2b。教育、培训和指导KL2学者计划和实施 高质量、高效率的多点研究和试验，并成功传播和实施研究成果； 目标2c。促进对传统上研究不足的特殊人群的研究，并加强努力解决 健康不平等；目标3.通过领导力培训促进多学科合作和团队科学， 指导和创建KL2学者“团队”侧重于解决具体的研究问题； 目标4.分享和传播KL2方案的成功要素，作为区域方案的典范 协作。KL2奖学金计划围绕深入教育、系统的面对面设计 活动，将来自广泛不同学科的学者与高级教员聚集在一起，他们促进了 发展他们的研究和专业技能。项目经验表明，一次“面对面” 结构，非常强调跨学科协作、同行指导和团队科学技能，是 对于KL2学者成为成功的独立临床和翻译研究人员至关重要。

Abstract The rationale and fundamental goal of the UCSF Clinical and Translational Science Institute KL2 Scholars Program is to train, mentor and equip succeeding generations of exceptional and diverse junior faculty investigators with the methodologic, analytic, leadership, and team science skills required to conduct transformative clinical and translational research. The Program's alumni, as individuals and as members of multidisciplinary teams, have made exceptional contributions to health sciences research across the lifespan. The proposed career development program is a key resource for clinical departments and research units across the campus, and does not duplicate existing training programs at UCSF. In continuing the successful KL2 program, with core faculty expertise in clinical and methodologic research, multisite studies and trials, and vulnerable populations, the Program provides a proven and vital resource for UCSF faculty from the Schools of Medicine, Nursing, Dentistry, and Pharmacy. In the proposed funding period the Program will leverage UCSF's unique strengths and partnerships with basic scientists, biopharmaceutical investigators, and industry innovators to position its Scholars to continue to advance the field of Clinical and Translational Science, with the following proposed Aims: Aim 1. To recruit a superb group of professionally and ethnically diverse UCSF junior faculty KL2 Scholars and to support them for up to 3 years as they progress toward research independence with individual NIH K and R awards; Aim 2. To expand and enhance training and mentoring at the frontiers of clinical and translational research, in partnership with other CTSI programs, emphasizing cutting-edge research methods; Aim 2a. Educate, train, and mentor KL2 Scholars to take full advantage of technology-enabled research methods; Aim 2b. Educate, train, and mentor KL2 Scholars to plan and conduct high-quality, efficient multisite studies and trials, and successfully disseminate and implement study results; Aim 2c. Promote research in traditionally understudied special populations and enhance efforts to address health inequities; Aim 3. Promote multidisciplinary collaboration and team science through leadership training, mentorship and the creation of KL2 Scholar “teamlets” focused on addressing a specific research problem; Aim 4. To share and disseminate the successful elements of the KL2 Program as a model for regional collaboration. The KL2 Scholars Program is designed around in-depth education, systematic in-person activities, bringing together Scholars from widely varied disciplines with senior faculty who facilitate development of their research and professional skills. Program experience demonstrates that a “face-to-face” structure, with a strong emphasis on interdisciplinary collaboration, peer mentorship, and team science skills, is essential for the KL2 Scholars to become successful independent clinical and translational investigators.