Neuroimaging Core

摘要 拟议修订的总体目标是开发Rush阿尔茨海默病的神经成像核心 核心中心(Rush ADCC)，将从Rush ADCC非洲中心建立神经成像数据资源 美国人和拉丁美洲人以及辅助研究，并将提供神经成像专业知识，以促进高 高质量、尖端、外部资助的研究，重点关注从正常衰老到轻度认知的过渡 损害(MCI)到阿尔茨海默病(AD)和其他痴呆症的早期阶段。具体地说， 神经成像核心将收集高质量的、多模式的、纵向的活体脑磁共振成像 (MRI)来自临床和拉丁裔核心的非洲裔和拉丁裔参与者的数据，他们同意 尸检，并将整合新的数据以及大量的体内和体外MRI数据 单独资助的研究，全部基于最先进的、统一的数据采集协议。神经影像 CORE将对体内和体外MRI数据进行彻底的质量检查和详细处理 数据库生成关于宏观结构、微观结构、化学和功能的丰富输出 老年人大脑的特征。拟议的神经成像核心将建立在Rush的优势之上 ADCC包括A)对非痴呆症患者的纵向临床评估，B)纵向 死前生物流体收集，以及C)大量人的死后生物标本收集， 许多人没有痴呆症。Rush ADCC的神经成像核心将广泛分发所有脑部MRI数据 并将结果处理给Rush ADCC内外的调查人员，并将提供神经成像 支持正常衰老、认知衰退、轻度认知障碍、阿尔茨海默病和 相关痴呆症。神经成像核心的贡献将刺激A)开发小说的研究 人脑和人的年龄相关神经病理和分子遗传学的成像生物标记物 来自同一人的血液，B)阐明支持认知和运动健康的大脑机制或 导致衰退，C)评估风险因素对大脑的影响，D)确定各种不同因素的作用 认知老化相关结果的种族/民族差异的脑特征。

ABSTRACT The overall goal of the proposed revision is to develop a Neuroimaging Core in the Rush Alzheimer’s Disease Core Center (Rush ADCC) that will build a resource of neuroimaging data from the Rush ADCC African Americans and Latinos and from ancillary studies, and will provide neuroimaging expertise to facilitate high quality, cutting edge, externally funded research focusing on the transition from normal aging to mild cognitive impairment (MCI) to the earliest stages of Alzheimer’s disease (AD) and other dementias. Specifically, the Neuroimaging Core will collect high quality, multi-modal, longitudinal in-vivo brain magnetic resonance imaging (MRI) data from African American and Latino participants of the Clinical and Latino Cores who agree to autopsy, and will integrate the new data along with a large volume of in-vivo and ex-vivo MRI data from separately funded studies, all based on state-of-the-art, uniform data acquisition protocols. The Neuroimaging Core will perform thorough quality checks and detailed processing of the in-vivo and ex-vivo MRI data in the database to generate rich output on the macro-structural, micro-structural, chemical, and functional characteristics of the older adult brain. The proposed Neuroimaging Core will build upon strengths of the Rush ADCC including A) longitudinal clinical assessment of persons who enroll without dementia, B) longitudinal ante-mortem biofluid collection, and C) post-mortem biospecimen collection from large numbers of persons, many without dementia. The Neuroimaging Core of the Rush ADCC will widely distribute all brain MRI data and processing results to investigators within and outside of the Rush ADCC, and will provide neuroimaging expertise in support of research efforts in normal aging, cognitive decline, mild cognitive impairment, AD and related dementias. The contributions of the Neuroimaging Core will stimulate research that A) develops novel imaging biomarkers of age-related neuropathologies and molecular genetics generated from human brain and blood from the same persons, B) elucidates brain mechanisms supporting cognitive and motor health or leading to decline, C) evaluates the effects of risk factors on the brain, and D) ascertains the role of various brain characteristics in racial/ethnic disparities of cognitive aging related outcomes.