2017 Western Epithelial Biology Society (WEBS) meeting

维持选择性上皮屏障和调节其他上皮功能--包括离子和 水运输、日常周转和先天免疫功能--是人类生理和免疫功能的关键方面 病理生理学。这些过程在肾脏和胃肠道等器官中尤为重要。 肠道，其中的干扰可以影响到几乎身体的每一个器官。此外，理解 调节这些组织的机制是NIDDK任务的一部分。认识到……的重要性 了解胃肠道、西海岸盐和水中的选择性通透性屏障 俱乐部(WCSWC)最初是一个地区性运输生理学会议。自那以后，它已经扩大到包括 各种器官系统中的上皮生理学、膜运输和细胞生物学，最近 更名为西方上皮生物学学会(WEB)会议。此应用程序请求资金 2017年网络大会将于2017年3月在加利福尼亚州阿维拉海滩举行。这将是有史以来的第38次 一系列独特的跨学科年度会议集中在上皮功能和细胞间/细胞内的作用。 蜂窝通信机制。自成立以来，这一年度会议一直为自己带来 初级调查人员和该领域的知名领导者一起展示他们最新的未发表的发现和 参与有意义的科学和社会互动。网络会议的非正式性质在以下方面是独特的 促进跨多个学科的讨论，并建立新的个人和科学联系 发展。因此，每年都有非常多的科学家回到这个会议上， 许多合作都是从会议开始的。参与者既有基础科学家，也有临床医生。 他们在调节正常和病变的上皮细胞方面有着共同的利益。2017年度主旨演讲嘉宾 将涵盖与NIDDK相关的两个重要主题：(I)常染色体的新途径和治疗靶点 显性多囊肾病和(Ii)肾脏嗅觉受体和短链脂肪酸在 血压控制。这次会议的目标是：(A)提供一个论坛，让调查人员 (特别是受训人员和初级教员)介绍他们的工作；(B)培养包容、热情、活泼和 互动氛围，突出该领域的最新研究，并通过提供 更深入地了解悬而未决的问题；(C)将来自几个学科的科学家聚集在一起， 受益于串扰和协作，但彼此之间通常不会或持续地进行互动；以及(D) 为支持和吸引年轻的研究人员进入上皮生物学领域提供持续的论坛 (研究生、博士后和初级教师)提供个性化的指导活动。通过以下位置的交互 在会议之后，我们将培养指导关系，从而增加女性的数量 以及在医学和科学领域代表性不足的群体，包括残疾人。所有演示文稿 在会议期间是令人兴奋的，及时的，旨在将新的发现转化为对疾病的更好的理解 机制、诊断、预防和治疗。之前的与会者经常期待这次会议， 新的参与者和年轻的科学家认识到这是一次无价的学习和职业经历。

Maintenance of the selective epithelial barrier and regulation of other epithelial functions—including ion and water transport, routine turnover, and innate immune functions—are crucial aspects of human physiology and pathophysiology. These processes are particularly important in organs such as the kidneys and gastrointestinal tract, and disturbances therein can affect almost every organ in the body. Moreover, understanding the mechanisms that regulate these tissues is part of the mission of the NIDDK. In recognition of the importance of understanding the selectively permeable barrier in the gastrointestinal tract, the West Coast Salt and Water Club (WCSWC) was started as a regional transport physiology meeting. It has since expanded to include epithelial physiology, membrane transport, and cell biology in a variety of organ systems and has recently changed its name to the Western Epithelial Biology Society (WEBS) meeting. This application requests funds for the 2017 WEBS conference to be held in Avila Beach, California in March, 2017. This will be the 38th in a unique series of annual interdisciplinary meetings focused on the role of epithelial function and inter-/intra- cellular communication mechanisms. Since its initiation, this annual meeting has prided itself on bringing together junior investigators and established leaders in the field to present their latest unpublished findings and engage in meaningful scientific and social interactions. The informal nature of the WEBS meeting is unique in fostering discussions that span multiple disciplines and enables new personal and scientific connections to develop. As a consequence, an extraordinarily high number of scientists return to this conference annually, and many collaborations start at the meeting. The participants are a good mix of basic scientists and clinicians who share common interests in the regulation of normal and diseased epithelia. The 2017 keynote speakers will cover two important topics relevant to the NIDDK: (i) novel pathways and therapeutic targets in autosomal dominant polycystic kidney disease and (ii) the role of kidney olfactory receptors and short-chain fatty acids in blood pressure control. The objectives of this conference are to: (a) provide a forum that allows investigators (especially trainees and junior faculty) to present their work; (b) foster an inclusive, intense, lively and interactive atmosphere that highlights the latest research in the field and enlightens participants by providing a deeper understanding of unresolved issues; (c) bring together scientists from several disciplines that would benefit from crosstalk and collaboration but do not typically or consistently interact with each other; and (d) provide a continuing forum for supporting and attracting young investigators to the field of epithelial biology (graduate students, postdocs and junior faculty) with personalized mentoring activities. Through interactions at the meeting and afterwards, we will foster mentoring relationships that can lead to increased number of women and underrepresented groups in medicine and science, including individuals with disabilities. All presentations during the meeting are exciting, timely, and aim to translate new findings into a better understanding of disease mechanisms, diagnosis, prevention and treatment. Previous participants regularly look forward to this meeting, and new attendees and young scientists recognize it as an invaluable learning and career experience.