Training in the Next Generation in Respiratory Science

7.项目摘要/摘要 这项建议是为了一个新的培训计划，题为“培训下一代呼吸系统科学”， 充分利用我们在当地的主要优势。历史上，加州大学圣迭戈分校有两笔T32奖学金，其中一笔是生理学(主要是GAS 一个是肺病学(主要是肺动脉高压)。随着时间的推移， 生理学的发展是为了解决新的问题，在我们看来，生理学并没有“死亡”。我们仍然专注于 综合功能和系统生物学的重要性，因此我们使用生理学的概念作为 跨呼吸科学的积分者在多个层面上进行了研究。虽然我们认为我们的科学是尖端的，但我们 值得自豪的是，我们的学员不仅关注单一分子、基因或受体，而且 牢记集成功能的重要性。我们建议继续我们的合作安排， 现任生理科主任Frank Powell博士和PCCMS现任主任Atul Malhotra博士 多个PI。自从马尔霍特拉博士到达加州大学圣迭戈分校以来，他在呼吸系统科学方面的培训有了很大的发展 在睡眠科学和重症监护方面带来了新的优势。因此，我们扩大了研究范围 为学员有效参与团队科学和不断更新他们的技能做准备的机会 解决他们职业生涯中将出现的新的研究问题。然而，要提高产品的质量 辅导，我们还删除了效率较低的导师，同时增加了更多由RO1资助的导师并将其正规化 基于研究培训的成功和当前研究资金的教师参与水平。为 例如，UCSD现在在儿科肺部疾病方面拥有相当大的实力(例如Victor Nizet、Gabby Haddad、Rob 奈特，吉姆·哈古德)。因此，我们将儿科作为我们工作的主要重点，这也解决了全国 这一地区的短缺。我们利用个人发展计划，由MPI、P接收器和高级管理人员监督 顾问，为我们所有的实习生提供适应不同背景和不同研究的人 兴趣。我们促进医学博士和博士之间的合作，确保每个人都有经验和 具备多学科研究能力，并确保所有学员在生理学方面有扎实的基础 为在任何水平上研究的问题提供临床背景的方法。我们推广 通过所有学员参与的共同活动，为学员提供凝聚力、团队精神和独特的身份认同 和导师，如每周学术活动会议(SAM)、我们的肺脏研究小组和每季度 撤退。我们致力于培训计划，包括学术生涯发展的各个阶段， 从摇篮到坟墓，包括将初级教员培养成独立的调查人员，甚至改善 指导我们最资深教职员工的技能。我们还将继续致力于使下一代 我们的长期记录和最近的招聘证明了这一点。缺乏一种 为多学科研究人员提供强大的渠道，他们可以将现代综合方法应用于 呼吸系统科学是一场危机，但这是一项我们完全有资格而且急于应对的挑战。

7. PROJECT SUMMARY/ABSTRACT This proposal is for a new training program entitled “Training the Next Generation in Respiratory Science” that capitalizes on our major local strengths. Historically UCSD had two T32 grants, one in Physiology (primarily gas exchange and exercise) and one in Pulmonology (primarily pulmonary hypertension). Over time, the field of physiology has evolved to solve new problems and in our view is not ‘dead’. We remain focused on the importance of integrated function and systems biology and thus we use the concepts of physiology as an integrator across respiratory science studied at multiple levels. While we view our science as cutting edge, we pride ourselves on the fact that our trainees do not just focus on a single molecule or gene or receptor but rather keep in mind the importance of integrated function. We propose to continue our collaborative arrangements with Drs. Frank Powell and Atul Malhotra, current Chiefs of the Divisions of Physiology and PCCMS, respectively, as Multiple PIs. Training in respiratory science at UCSD has evolved considerably since Dr. Malhotra’s arrival as he brought in new strengths in sleep science as well as in critical care. Thus, we have expanded the research opportunities to prepare trainees for participating effectively in team science and continually renewing their approach to novel research questions that will arise during their careers. However, to improve the quality of mentoring, we also removed less effective mentors while adding more RO1-funded preceptors and formalizing the levels of faculty participation based on success in research training and current research funding. For example, UCSD now has considerable strength in Pediatric Lung Disease (e.g. Victor Nizet, Gabby Haddad, Rob Knight, Jim Hagood). Thus we made Pediatrics a major focus of our efforts which also addresses the national shortage in this area. We utilize individual development plans, overseen by the MPIs, Preceptors and senior advisors, for all of our trainees to accommodate people with diverse backgrounds and different research interests. We promote collaboration between MDs and PhDs, insure that everyone has experience and competency in multidisciplinary research, and insure all of our trainees have a strong foundation in physiological approaches that provides a clinical context for research problems studied at any level. We promote cohesiveness, team spirit and a unique identity for our trainees via common activities involving all of our trainees and mentors such as weekly scholarly activity meetings (SAMs), our Lung Investigator Group, and quarterly retreats. We are committed to a training program that includes every phase of academic career development, from ‘cradle to grave’ including developing junior faculty into independent investigators, and even improving the mentoring skills in our most senior faculty. We also remain committed to diversifying the next generation of respiratory scientists as demonstrated by our long-term track-record and recent recruitments. The lack of a robust pipeline for multidisciplinary researchers who can apply modern integrative approaches to problems in respiratory science is a crisis, but it is a challenge that we are well-qualified and anxious to address.