HIV and Aging: From the Mitochondria to the Metropolis

艾滋病毒与衰老：从线粒体到大都市 摘要 在2014年10月我们首次由NIA支持的艾滋病毒和老龄化会议取得成功的基础上，主要 R13申请的目的是：a)促进艾滋病毒和老龄化科学的发展，并加快翻译速度 通过在5年内举办3次会议，将调查结果向社区公布；以及b)创建和建立 不同的多学科科学家将进行转化性研究，重点是 与艾滋病毒和老龄化有关的知识和研究。艾滋病办公室的调查结果和建议 艾滋病毒与老龄化研究工作小组(OAR WG)是我们 会议。我们的目的是吸引和聚集专家、临床医生、早期研究人员和 来自艾滋病毒和老龄化领域的社区领导人。我们预计这些会议将导致以下成果 成果：a)增加该领域的知识，并为基础和临床翻译提供可行的机制 向艾滋病毒/艾滋病患者(PLWH)社区提供科学发现(即从“线粒体到 大都市“)；b)侧重于临床和研究差距的跨学科协作；c)制定 新的艾滋病毒和老龄化研究人员的流水线和与研究相关的研究建议的制定 审查组工作组概述并通过各次会议实施的议程；d)分发会议 向广泛的专业人士提供内容。会议将由执行委员会和科学委员会计划 有来自社区的大量代表，并包括内容专家，以规划第二和 第三次会议。执行董事会将由共同指导埃默里的CFAR科学工作的Co-Pi领导 艾滋病毒和老龄问题小组与CFARs和老龄中心的大力合作。所有会议都将是 在佐治亚州亚特兰大举行。三个会议的具体主题包括：功能健康(2017)：a 以人为中心的生物行为方法，以最大化健康和健康，承认和 解决内部(例如，健康行为、个人对压力和疾病的反应)和外部(例如， 环境健康)影响老龄化的因素。老龄化与特殊人群(2019)：老年人的独特需求 需要专门干预和治疗的老年PLWH亚群。它们包括种族/民族 少数民族；妇女；男男性接触者；变性人；退伍军人；吸毒者；合并感染丙型肝炎的人； 无家可归的或居无定所的。健康的人口决定因素(2021年)：个人行为的范围， 遗传、生物和社会决定因素，包括社会/社会特征、自然环境、 以及医疗服务，这塑造了老年PLWH的健康和健康。所有三个会议和他们的 相应的主题涉及审咨委工作组确定的关键知识差距。每一次会议都将编织 基础和生理科学、行为/心理社会科学、临床护理和 妇幼保健院及其照顾者的社区经验和观点。

HIV and Aging: From the Mitochondria to the Metropolis ABSTRACT Building on the success of our first NIA-supported HIV and Aging conference held in October 2014, the primary aims of this R13 application are to: a) Advance the state of the science on HIV and aging and speed translation of findings to the community by conducting 3 conferences over a 5 year period; and b) Create and build a pipeline of diverse multidisciplinary scientists who will conduct translational research focusing on the gaps in knowledge and research related to HIV and Aging. The findings and recommendations from the Office of AIDS Research Working Group on HIV and Aging (OAR WG) form the foundation and framework for our conferences. Our intent is to attract and bring together experts, clinicians, early stage investigators, and community leaders from the fields of both HIV and Aging. We expect these conferences to lead to the following outcomes: a) increase knowledge in the field and provide a viable mechanism for translating basic and clinical science findings to the community of persons living with HIV/AIDS (PLWH) (i. e, from the “mitochondria to the metropolis”); b) Interdisciplinary collaborations focused on clinical and research gaps; c) Development of a pipeline of new HIV and Aging researchers and development of research proposals related to the research agenda outlined by the OAR WG and operationalized via the conferences; d) dissemination of conference content to a broad range of professionals. The conferences will be planned by Executive and Scientific Boards with substantial representation from the community and include content experts for planning the second and third conferences. The Executive Board will be led by Co-PI’s who co-direct Emory’s CFAR Scientific Working Group on HIV and Aging with strong collaboration by CFARs and Centers for Aging. All conferences will be held in Atlanta, GA. The specific themes of the three conferences include: Functional Wellness (2017): A person-centered, bio-behavioral approach to maximizing health and wellness that acknowledges and addresses both internal (e.g., health behavior, individual responses to stress and illness) and external (e.g., environmental health) factors that impact aging. Aging and Special Populations (2019): The unique needs of sub-groups of aging PLWH who require specialized interventions and treatment. They include racial/ethnic minorities; women; MSM; transgender; veterans; substance users; those co-infected with hepatitis C; and homeless or marginally housed. Population Determinants of Health (2021): The range of individual behavioral, genetic and biological, and social determinants, including social/societal characteristics, physical environment, and health services, that shape health and wellness of older PLWH. All three conferences and their corresponding themes address critical knowledge gaps identified by the OAR WG. Each conference will weave together basic and physiologic science, behavioral/psychosocial science, clinical aspects of care, and the community experiences and perspectives of PLWH and their caregivers.