IGF::OT::IGF High-plex Pharmacodynamic Biomarker Assay

药效学是药物诱导的生物系统反应，可以使用分子、生理和医学成像技术进行评估和定量。作为DCTD对靶向癌症治疗的支持的一部分，有必要开发有用和可靠的检测方法，以指导药物开发，并用于了解作为临床试验患者药物反应评估一部分的生化变化。该项目支持设计、开发、验证和证明一种新的多重检测方法的适用性，用于分析和定量肿瘤细胞死亡或存活的重要生物标志物。这些强大的分析将被创建，以支持在人类临床试验期间收集的体液肿瘤活检的测试，并将研究ER应激，氧化DNA损伤和修复以及肿瘤细胞死亡之间的联系。

Pharmacodynamics is the drug-induced response of a biological system and it can be assessed and quantitated using molecular, physiological and medical imaging techniques. As part of DCTD’s support for targeted cancer therapies, it is necessary to develop useful and reliable assays that can guide drug development and be used to understand the biochemical changes that are part of the evaluation of drug response in clinical trial patients. This project supports the design, development, validation and demonstration of fitness-for-purpose of a new multiplex assay for the analysis and quantitation of important biological markers of tumor cell death or survival. These robust assays will be created to support testing of humor tumor biopsies collected during the conduct of human clinical trials and will investigate the linkage between ER stress, oxidative DNA damage and repair, and tumor cell death.