Animal and Pathology Core

动物/病理学核心的目标是： 目标A.收集、加工、存档和分发人类和动物组织(项目1、2、3、4) 目标B.进行肿瘤植入和照明；协助其他小鼠治疗(项目2、3、4) 目标C.协助小鼠尸检(达勒姆博士)并协调动物和人类肿瘤的移动 病理(人类或兽医，视情况而定)之间的免疫组织化学分析样本 和项目负责人的实验室。 Core B的优势在于，它将提供一致的动物模型、动物治疗、组织收集和 对PPG中的项目进行病理分析。鉴于提供PDT的“高科技”性质，这是 尤其重要的是。核心将作为中心点，以确保组织将被收集和分发 以一致的方式，根据我们的SOP，这一过程将使用详细的数据进行很好的记录 收集表格包含在核心B的附录中；西德尼·埃文斯博士将担任核心B的主管； 达勒姆将负责尸检后与动物相关的免疫组织化学任务(目标C)。这个 核心B的功能可分为动物亚核和病理亚核。 动物分中心将负责 1)协助绩效指标制定、提交和维护IACUC提案 2)订购动物 3)进行项目间动物工作，包括肿瘤植入、照明、组织采集 病理分中心将： 1)协助动物和人体组织/血液的收集、处理和存档或储存 2)监督小鼠的身体解剖、组织的收集和提交以供染色/组织病理学审查

The aims of the Animal/Pathology Core are to: AIM A. Collect, process, archive and distribute human and animal tissues (Projects 1,2,3,4) AIM B. Perform tumor implantations and illuminations; assist in other treatments of mice (Projects 2,3,4) AIM C. Assist in mouse autopsies (Dr. Durham) and coordinate the movement of animal and human tumor samples for immunohistochemical analysis between Pathology (human or veterinary, as relevant) and the laboratories of Project Leaders. The strength of Core B is that it will provide consistent animal models, animal treatments, tissue collection and pathologic analyses for the projects in this PPG. Given the “high tech” nature of delivering PDT, this is particularly important. The Core will act as a center point to assure that tissues will be collected and distributed in a consistent manner, based on our SOPS, and this process will be well documented using detailed data collection forms included in the Appendix of Core B. Dr. Sydney Evans will be the director of Core B; Dr. Durham will be responsible for the animal-related immunohistochemistry tasks after autopsy (Aim C). The functions of Core B can be separated into the ANIMAL and the PATHOLOGY subcores. The ANIMAL SUBCORE will be responsible for 1) Aiding the PIs in developing, submitting and maintaining IACUC proposals 2) Ordering animals 3) Performing inter-project animal work, including tumor implantation, illumination, tissue collection The PATHOLOGY SUBCORE will: 1) Aid in the collection, processing, and archiving or storage of animal and human tissues/blood 2) Oversee murine autopsies, collection and submission of tissues for staining/histopathological review