PDX Core

PDX核心项目总结 患者衍生异种移植(PDX)开发和试验中心(PDTC)PDX核心的目标是 建立和维护PDX品系，用于进行动物临床前试验 标准护理疗法；通过开发和开发 维护PDX开发、维护和维护的共享标准操作程序(SOP) 实验和病原体测试；提供基础设施来管理大型PDX收集和 生成、存储和管理由项目生成的基于PDX的实验数据；促进 PDXNet程序之间的PDX模型；并促进将实验数据传输到PDTC 生物统计学和生物信息学核心与PDTC PDXNet数据共享和协调中心的关系 治疗对个体患者肿瘤的分子特征的反应。我们的PDTC PDX核心电流 包括162条乳房PDX线，可用于我们PDTC中心和整个PDXNet计划内的项目。

PDX CORE PROJECT SUMMARY The goals of the patient-derived xenograft (PDX) Development and Trial Center (PDTC) PDX Core are to establish and maintain PDX lines for the purpose of conducting animal preclinical trials using experimental and standard-of-care therapeutics; to promote quality-control, reproducibility, and collaboration by developing and maintaining shared Standard Operating Procedures (SOPs) for PDX development, maintenance, experimentation, and pathogen testing; to provide infrastructure to manage large PDX collections and to generate, store, and manage PDX-based experimental data generated by the projects; to facilitate exchange of PDX models between the PDXNet program; and to facilitate transfer of experimental data to the PDTC Biostatistics and Bioinformatics Core and the PDTC PDXNet Data Commons and Coordinating Center to relate treatment responses to the molecular characteristics of individual patients’ tumors. Our PDTC PDX Core current comprises 162 breast PDX lines available for projects within our PDTC Center and across the PDXNet program.