Caenorhabditis Genetics Center

小杆线虫遗传中心（CGC）是唯一的综合性储存库和配送中心， 线虫秀丽隐杆线虫是生物医学研究的首要模式生物。整体 目的是促进对该动物资源的研究。通过获取、维护和 分布着具有遗传特征的线虫种群。世界各地的研究人员利用基因库 从CGC在不同的基础和应用研究工作中获得，以及动手教学 实验科学使用这种首要模式生物的研究已经导致了对基础生物学的基本见解。 生物学机制，包括程序性细胞死亡的遗传基础，microRNA的发现， RNA干扰在动物中的作用机制线虫也被证明对于理解 癌症进展和其他疾病，包括阿尔茨海默氏症和帕金森氏症，以及 揭示了人类发展的基本机制此外，C. elegans作为一个关键模型， 阐明了我们对与人类和牲畜健康相关的寄生线虫的理解。为 C.只有一般的库存中心。CGC是一个非常重要的国际研究资源， 支持这些不同领域的研究和教育工作。CGC提供超过30，000个 每年向数千个实验室分发菌株;收集了超过19，000种独特的菌株， 随着该领域的发展，CGC不仅促进了研究，而且还确保了 有价值的菌株得以保存。CGC通过在线订购系统根据要求分发菌株。 用户付费计划有助于支付费用和支持CGC活动。CGC还包括一项研究 这是一个旨在加强CGC收集的组件。我们密切关注用户需求，与C. 线虫社区，并专注于遗传工具，给了我们一个独特的视角，在设计一个研究 成分将追求两个目标，一个是通过产生 染色体内倒位用作交换抑制剂。另一个目标是完成收集 microRNA基因的无效突变。

The Caenorhabditis Genetics Center (CGC) is the sole comprehensive repository and distribution center for the nematode Caenorhabditis elegans, a premier model organism for biomedical research studies. The overall objective of this animal resource is to promote research on C. elegans by acquiring, maintaining, and distributing genetically characterized nematode stocks. Researchers throughout the world use genetic stocks obtained from the CGC in diverse basic and applied research endeavors, as well as for hand-on teaching of experimental science. Studies using this premier model organism have led to fundamental insights into basic biological mechanisms, including the genetic basis of programmed cell death, the discovery of microRNAs, and the mechanism of RNA interference in animals. The nematode has also proved important for understanding mechanisms of cancer progression and other diseases including Alzheimer's and Parkinson's, as well as for revealing basic mechanisms underlying human development. In addition, C. elegans serves as a key model for illuminating our understanding of parasitic nematodes with relevance to human and livestock health. As the only general stock center for C. elegans, the CGC is an extremely important international research resource, supporting research in these diverse areas and educational endeavors. The CGC provides more than 30,000 strains are distributed per year to thousands of laboratories; with a collection of over 19,000 unique strains, still expanding in proportion to the growth of the field, the CGC not only facilitates research, but also ensures that valuable strains are preserved. The CGC distributes strains upon request through an on-line ordering system. A scheme of user fees helps to defray costs and support CGC activities. The CGC also includes a research component aimed at enhancing the CGC collection. Our close monitoring of user needs, ties with the C. elegans community, and focus on genetic tools has given us a unique perspective in devising a research component. Two aims will be pursued, one focused on expanding the genetic tool-kit by generating intrachromosomal inversions for use as crossover suppressors. The other aim is to complete the collection of null mutations in microRNA genes.