Program 3: Cancer BiologyProgram (CBP)

项目摘要/摘要：癌症生物学计划(CBP) 癌症生物学计划(CBP)的目标是确定癌症的致病机制 发展和进步。作为亚利桑那大学癌症基础科学的主要平台 癌症中心，癌症生物学项目寻求促进对该复合体的基础知识 在癌症中错乱的生物网络，并表征这些复合体之间的相互作用 促进癌症发生和肿瘤进展的生物网络和环境。翻译： 目前癌症预防和治疗新方法的发现和发展是通过 方案间协作和癌症中心支持。该计划分为三个主要部分 主题，包括基因组不稳定性和基因表达的表观遗传控制，信号网络 癌症发生和肿瘤进展，以及侵袭和转移，有四个目的：(I)调查 癌症发生和发展的机制以及控制癌症的细胞机制的特征 转移，(Ii)确定网络和调控途径作为潜在的标志物或目标，在预防和 治疗，(3)促进方案内和方案间的合作，以加强翻译研究 来自临床前小鼠模型和人类组织的连续体与临床试验相关，以及(Iv)促进 与亚利桑那州和西南部的个人特别相关的研究方向。癌症生物学 方案通过建立工作组、会议和研讨会来实现这些目标，并 发展跨学科科学团队；教师招聘、会员发展和 指导，并利用发展基金促进有针对性的研究；以及指导和支持 共享资源。CBP有49名成员，代表加州大学21个不同的系 亚利桑那州。CBP成员发表了390篇与癌症相关的手稿，其中30%是内部 程序性的和36%的是程序性的。截至2015年9月1日，CBP计划获得1180万美元 年度拨款总额为250万美元，其中250万美元来自NCI，830万美元来自其他同行评审资金。CBP已经 通过其成员对以下化合物致癌机制的基础研究产生的区域影响 西南地区普遍存在的环境致癌物质。最后，该计划被投资于使用现代的、高级的 通过基因组平台来开发、增强和实施精准医学。不断扩大的 拉美裔美国人在该州人口中的代表性推动了对癌症健康的更多研究 这一人群中的差异。

Project Summary / Abstract: Cancer Biology Program (CBP) The goal of the Cancer Biology Program (CBP) is to identify etiologic mechanisms underlying cancer development and progression. As the main basic science of cancer platform for the University of Arizona Cancer Center, the Cancer Biology Program seeks to advance fundamental knowledge of the complex biological networks that are deranged in cancer and to characterize interactions between these complex biological networks and the environment that promote carcinogenesis and tumor progression. Translation of current findings and development of novel approaches to cancer prevention and treatment is facilitated through inter-programmatic collaborations and Cancer Center support. The program is organized into three major themes, including Genomic Instability and Epigenetic Control of Gene Expression, Signaling Networks in Carcinogenesis and Tumor Progression, and Invasion and Metastasis, with four aims: (i) to investigate mechanisms of cancer initiation and progression and to characterize cellular mechanisms that control cancer metastasis, (ii) to identify networks and regulatory pathways as potential markers or targets in prevention and treatment, (iii) to promote intra- and inter-programmatic collaborations to enhance translational research along the continuum from pre-clinical mouse models and human tissue correlates to clinical trials, and (iv) to foster research directions of particular relevance to individuals in Arizona and the Southwest. The Cancer Biology Program achieves these aims through establishment of working groups, conferences and seminars, and development of inter-disciplinary scientific teams; faculty recruitment, membership development and mentoring, and the use of developmental funds to spur targeted research; and, guidance and support of the shared resources. The CBP has 49 Members representing 21 different departments at the University of Arizona. CBP Members have published 390 cancer-relevant manuscripts, of which 30% were intra- programmatic and 36% were inter-programmatic. As of September 1, 2015, the CBP Program secured $11.8M total annual grant dollars with $2.5M from the NCI and $8.3M in other peer-reviewed funding. The CBP has regional impact through its members' basic research into the carcinogenic mechanisms of arsenicals that are pervasive environmental carcinogens in the Southwest. Finally, the Program is invested in using modern, high throughput genomic platforms to develop, enhance, and implement precision medicine. The expanding representation of Hispanic Americans in the State's population impels increased research into cancer health disparities in this population.