2017 Plant Metabolic Engineering: Plant Engineering in the Synthetic Biology Era Gordon Research Conference and Gordon Research Seminar

项目总结 自从分子生物学出现以来，植物新陈代谢的研究进展迅速，并已 随着组学/大数据时代的到来而加速。基于这项研究的工程学可以为 全球生物经济，通过开发新药，为原料和燃料创造绿色生产平台， 以及增加粮食供应。合成生物学可以极大地提高这种潜力，但它的概念和 这种方法在植物科学中还不是很普遍。从本质上讲，合成生物学扩展了新陈代谢 工程工具箱采用标准化、模块化等设计理念，通过设计非 自然途径和产物，以及利用计算模拟和DNA写入。合成生物学 因此需要跨学科的交流。植物代谢工程GRC将汇集领先的 植物和微生物工程师、合成生物学家、计算生物化学家和资助机构的科学家。 该计划旨在：i)突出合成生物学如何改变新陈代谢的用途；ii)展示尖端技术 来自卫生和生物基经济部门的工程和发现研究；三)考虑植物与 微生物是‘底盘生物体’；以及iv)讨论工业和工业领域的合成生物学工程 政府的观点。 成功的植物代谢工程需要来自不同领域的研究人员的投入。这 GRC提供了这些不同科学家群体之间仅有的互动论坛之一。 与科学使命相辅相成的是GRC致力于聘用下一代科学家。 像过去一样，为研究生和博士后举办的为期两天的戈登研究研讨会(GRS)将 在此GRC之前。GRS允许研究生和博士后向同行展示他们的工作，并 公开讨论该领域当前的问题和未来发展方向。这种组合使GRS参与者能够 建立一个领域的所有权，组成一个社区，并组织和运营一个职业生涯早期的会议场所 科学家。GRS参与者将留在GRC，进一步加强教育 是这次会议的组成部分。此外，2017年GRC大约三分之一的演讲者将是初级 参加程序化课程的教职员工或研究生、博士后或初级教职员工 他在一个特别的“新星”会议上发表了讲话。

PROJECT SUMMARY Research in plant metabolism has advanced rapidly since the advent of molecular biology, and has accelerated with the arrival of the omics/big data era. Engineering based on this research can contribute to the global bioeconomy by developing new drugs, generating green production platforms for feedstocks and fuels, and enhancing food supplies. Synthetic biology can greatly increase this potential, but its concepts and methods are not yet widespread in plant science. In essence, synthetic biology extends the metabolic engineering toolbox by adopting design concepts such as standardization and modularity, by devising non- natural pathways and products, and by exploiting computational simulation and DNA writing. Synthetic biology thus requires cross-disciplinary exchange. The Plant Metabolic Engineering GRC will bring together leading plant and microbial engineers, synthetic biologists, computational biochemists, and funding agency scientists. The program aims to: i) highlight how synthetic biology can repurpose metabolism; ii) present cutting-edge engineering and discovery research from the health and biobased economy sectors; iii) consider plants versus microbes as ‘chassis organisms’; and iv) discuss synthetic biology-enabled engineering from industry and government perspectives. Successful plant metabolic engineering requires input from researchers across a wide variety of fields. This GRC provides one of the only forums interactions among these diverse groups of scientists. Complementing the scientific mission is the GRC's commitment to engaging the next generation of scientists. As in the past, a two-day Gordon Research Seminar (GRS) for graduate students and postdoctorals will precede this GRC. The GRS allows graduate students and postdoctorals to present their work to peers, and to openly discuss current issues in the field and future directions. This combination allows GRS participants to establish ownership of a field, to form a community, and to organize and run a meeting venue of early career scientists. GRS participants will be expected to stay for the GRC, further enhancing the educational component of this conference. In addition, roughly 1/3 of the speakers in the 2017 GRC will either be junior faculty members presenting in programmed sessions or be graduate students, postdoctorals, or junior faculty speaking in a special 'rising stars' session.