Glutamatergic and GABAergic projections from the ventral pallidum control motivated behaviors

项目摘要 介导厌恶和奖励的回路功能障碍是精神障碍的基础，如焦虑， 抑郁和成瘾然而最近的研究已经确定了外侧缰核，中缝和腹侧缰核， 被盖区作为调节厌恶和奖赏的关键区域，很少有人知道传入影响这些 结构.在这个提议中，我们将研究腹侧苍白球及其投射在 厌恶和奖赏编码。在目标1中，我们将描述谷氨酸能和GABA能 神经元在位置偏好任务中调节厌恶和奖励。在目标2中，我们将描述如何 谷氨酸能和γ-氨基丁酸能向下游目标的投射介导了某个地方的厌恶和奖励 偏好任务在目标3中，我们将使用单单位记录技术来表征 腹侧苍白球中的GABA能神经元在成本效益决策中编码厌恶和奖励 制作任务。我们还将测试VP突触能神经元是否是执行 行为选择了解腹侧苍白球回路是如何调节厌恶和奖赏的， 指导治疗几种精神疾病。

Project Summary Dysfunction in circuits mediating aversion and reward underlies mental disorders, such as anxiety, major depression and addiction. Whereas recent studies have identified the lateral habenula, raphe and ventral tegmental area as key regions mediating aversion and reward, little is known afferents influencing these structures. In this proposal, we will investigate the role of the ventral pallidum and its projections in aversion and reward encoding in mice. In Aim 1, we will characterize how glutamatergic and GABAergic neurons mediate aversion and reward in a place preference task. In Aim 2, we will characterize how glutamatergic and GABAergic projections to downstream targets mediate aversion and reward in a place preference task. In Aim 3, we will use single-unit recording techniques to characterize how glutamatergic and GABAergic neurons in the ventral pallidum encode aversion and reward in a cost-benefit decision making task. We will also test whether VP glutamatergic neurons are necessary for execution of behavioral choice. Understanding how ventral pallidal circuits mediates aversion and reward will help guide treatment for several mental disorders.