Neuroimaging Core

摘要 拟议修订的总体目标是制定一个神经影像学核心在拉什阿尔茨海默病 核心中心（拉什ADCC），将建立一个资源的神经成像数据从拉什ADCC非洲 美国人和拉丁美洲人和辅助研究，并将提供神经影像学专业知识，以促进高 高质量，尖端，外部资助的研究，重点是从正常老化到轻度认知的过渡 在阿尔茨海默病（AD）和其他痴呆的早期阶段，MCI是一种重要的神经功能障碍（MCI）。具体而言是 Neuroimaging Core将收集高质量、多模态、纵向的活体脑磁共振成像 (MRI)来自临床和拉丁美洲核心研究的非裔美国人和拉丁美洲参与者的数据，这些参与者同意 尸检，并将整合新的数据沿着大量的体内和体外MRI数据，从 单独资助的研究，都基于最先进的，统一的数据采集协议。神经影像学 Core将对体内和体外MRI数据进行全面质量检查和详细处理， 数据库生成丰富的输出上的宏观结构，微观结构，化学和功能 老年人大脑的特征。拟议的神经影像核心将建立在拉什的优势之上 ADCC包括：A）对无痴呆症患者的纵向临床评估，B）纵向 死前生物流体收集，和C）从大量人的死后生物样本收集， 许多人没有痴呆症。Rush ADCC的神经成像核心将广泛分发所有大脑MRI数据 并将处理结果提供给Rush ADCC内外的研究人员，并将提供神经成像 支持正常衰老、认知功能减退、轻度认知功能障碍、AD和 相关的痴呆症神经影像学核心的贡献将刺激研究，A）开发新的 从人脑产生的年龄相关神经病理学和分子遗传学的成像生物标志物， 来自同一人的血液，B）阐明支持认知和运动健康的脑机制，或 C）评估风险因素对大脑的影响，D）确定各种风险因素的作用。 认知老化相关结果的种族/民族差异中的大脑特征。

ABSTRACT The overall goal of the proposed revision is to develop a Neuroimaging Core in the Rush Alzheimer’s Disease Core Center (Rush ADCC) that will build a resource of neuroimaging data from the Rush ADCC African Americans and Latinos and from ancillary studies, and will provide neuroimaging expertise to facilitate high quality, cutting edge, externally funded research focusing on the transition from normal aging to mild cognitive impairment (MCI) to the earliest stages of Alzheimer’s disease (AD) and other dementias. Specifically, the Neuroimaging Core will collect high quality, multi-modal, longitudinal in-vivo brain magnetic resonance imaging (MRI) data from African American and Latino participants of the Clinical and Latino Cores who agree to autopsy, and will integrate the new data along with a large volume of in-vivo and ex-vivo MRI data from separately funded studies, all based on state-of-the-art, uniform data acquisition protocols. The Neuroimaging Core will perform thorough quality checks and detailed processing of the in-vivo and ex-vivo MRI data in the database to generate rich output on the macro-structural, micro-structural, chemical, and functional characteristics of the older adult brain. The proposed Neuroimaging Core will build upon strengths of the Rush ADCC including A) longitudinal clinical assessment of persons who enroll without dementia, B) longitudinal ante-mortem biofluid collection, and C) post-mortem biospecimen collection from large numbers of persons, many without dementia. The Neuroimaging Core of the Rush ADCC will widely distribute all brain MRI data and processing results to investigators within and outside of the Rush ADCC, and will provide neuroimaging expertise in support of research efforts in normal aging, cognitive decline, mild cognitive impairment, AD and related dementias. The contributions of the Neuroimaging Core will stimulate research that A) develops novel imaging biomarkers of age-related neuropathologies and molecular genetics generated from human brain and blood from the same persons, B) elucidates brain mechanisms supporting cognitive and motor health or leading to decline, C) evaluates the effects of risk factors on the brain, and D) ascertains the role of various brain characteristics in racial/ethnic disparities of cognitive aging related outcomes.