Macrophage Migration Inhibitory Factor (MIF): Pathological and Therapeutic Significance in Post- Infarct Inflammation

炎症反应介导的缺血性心脏损伤对预后有重大影响。MIF是调节和放大炎症反应的中心因子，但它在心脏病中的作用在很大程度上仍未得到检验。该项目将首次研究MIF在缺血性心脏病中的关键作用，并将为开发针对缺血性心脏损伤的新的抗炎治疗策略建立重要的实验证据。

Ischemic heart injury mediated by the inflammatory response has a significant impact on the prognosis. MIF is a central factor mediating and amplifying the inflammatory response but its role in heart disease remains largely untested. This project will study, for the first time, the crucial role of MIF in ischemic heart disease and will establish important experimental evidence for developing new anti-inflammation therapeutic strategies against ischemic heart injury.