Macrophage uncoupling protein-2 regulation and expression in inflammatory joint disease and hyperoxic lung damage

氧自由基（OR）是由白色血细胞（WBC）在抵御微生物和癌细胞时产生的。然而，过量的生产也会损害正常组织，例如在接受过多氧气的肺部（高氧肺损伤）或发炎的关节中。一种类型的白细胞，巨噬细胞有一种名为UCP2的蛋白质，它限制了OR形成的数量。该项目旨在了解巨噬细胞如何激活UCP2，以及它们是否在炎症性关节炎和高氧肺损伤中这样做。

Oxygen radicals (OR) are made by white blood cells (WBC) when they protect against microbes and cancer cells. However, excessive production also damages normal tissue, for example in lungs that receive too much oxygen (hyperoxic lung damage) or in inflamed joints. One type of WBC, the macrophage has a protein named UCP2, that limit the amount of OR formation. This project aims to find out how macrophages activate UCP2 and whether they do so in inflammatory arthritis and hyperoxic lung damage.