Mechanisms of Action of MBCT-PD: A Pilot Study

修改项目摘要/摘要部分 项目摘要 产后抑郁症是产后最普遍的精神病理学类型之一，对母亲和婴儿都有不利影响。目前，非药物干预措施的数量有限，特别是为降低高危样本中产后抑郁症风险而开发的干预措施（例如，有抑郁症病史的女性）。阐明减少产后抑郁症的有效治疗的作用机制是至关重要的，因为它将有助于了解参与的机制以及怀孕期间的干预如何优化这些机制的参与。这项先导性翻译功能磁共振成像研究提出，以检查是否认知控制和情绪调节是潜在的作用机制，在产后期间，无论是在行为和神经水平，基于正念的认知疗法-围产期抑郁症（MBCT-PD）。MBCT-PD是一种基于小组的治疗，专注于发展正念和认知行为技能，并已被证明在减少抑郁症状和产后抑郁症的出现方面有效。此外，本研究还探讨了潜在的行动机制是否会影响风险的代际传递，即报告的负面婴儿情绪。

Modified Project Summary/Abstract Section Project Summary Postpartum depression is one of the most pervasive types of psychopathology postpartum, with detrimental effects for both mothers and their infants. There are a limited number of non-pharmacological interventions at present, particularly interventions developed to reduce risk of postpartum depression in at-risk samples (e.g., women with a prior history of depression). Elucidating the mechanisms of action of efficacious treatments that reduce postpartum depression is critical, as it will facilitate understanding what mechanisms are engaged and how intervention during pregnancy can optimize engagement of these mechanisms. This pilot translational fMRI study proposes to examine whether cognitive control and emotion regulation are potential mechanisms of action during the postpartum period, both at the behavioral and neural level, of Mindfulness-Based Cognitive Therapy – Perinatal Depression (MBCT-PD). MBCT-PD is a group-based therapy that focuses on developing mindfulness and cognitive behavioral skills and has been shown to be efficacious in reducing depressive symptoms and emergence of major depressive disorder postpartum. Additionally, the study proposes to explore whether engagement of potential mechanisms of action effect intergenerational transmission of risk, namely reported negative infant emotionality.