Rodent Behavior Core

摘要-啮齿动物行为核心 我们中心将有一个啮齿动物行为核心，为动物研究团队提供科学支持。这一核心 将为项目团队提供对中心成功至关重要的服务。核心将执行 疼痛/控制手术在大鼠和小鼠的所有实验室参与中心。最重要的是 核心将进行一整套行为测试，以评估神经性疼痛的多个组成部分， 表型及其对药物寻求行为的影响。有一个共同的空间来进行所有的行为测试 将允许这些复杂方案的更高再现性。沿着这条路线，核心人员不仅将 进行行为评估，但也将提供培训和监督外部人员， 将由本中心资助的个别实验室指定，以帮助进行测试。芯会 进一步的目标是优化和完善行为协议，以理想地适合他们评估复杂的 疼痛和药物寻求表型之间的行为相互作用。这些努力的结果将在下文中加以总结。 详细的标准作业程序，将在网上公布，并将提供给所有 科学界。最后，核心将允许实验室目前不直接参与疼痛和/或 药物成瘾研究通过提供初步数据参与这类研究 关键是要申请外部资金。因此，这一核心将在扩大科学领域中发挥关键作用。 社区对这个非常重要的主题感兴趣，这是NIH最紧迫的优先事项之一。

Abstract - Rodent Behavior Core Our Center will have a Rodent Behavior Core to give scientific support to the animal research teams. This Core will provide the program team with services that are critical to the Center’s success. The Core will perform pain/control surgeries in rats and mice for all the laboratories involved in the Center. Most importantly the core will perform a whole set of behavioral tests to assess the multiple components of the neuropathic pain phenotype and its effect on drug seeking behavior. Having a common space to perform all the behavioral tests will allow higher reproducibility of these complex protocols. Along this line, the Core personnel will not only perform the behavioral assessments, but will also provide training and supervision to external personnel that will be designated by the individual laboratories part of this Center Grant to help with the tests. The Core will further aim to optimize and refine the behavioral protocols to ideally suit them to assess the complex behavioral interaction between pain and drug seeking phenotype. The results of such effort will be summarized in highly detailed standard operating procedures that will be posted online and will be available to the entire scientific community. Finally, the Core will allow laboratories currently not directly involved with pain and/ or drug addiction research to become involved in this type of research by providing them with preliminary data critical to apply for external funding. Thus, this Core will play a critical role in expanding the scientific community interested in this very important topic, which represents one of the most urgent priorities for NIH.