Lymphatic Forum 2019

总结/摘要 2019年淋巴论坛是计划中的会议系列中的第二次，汇集了来自 在健康和疾病中研究生物学的人。淋巴管系统是一个相对 研究不足，但心血管系统的重要组成部分，耦合组织实质， 静脉血通过淋巴流经复杂的淋巴管网络。它输送液体，大分子， 脂质、组织分解代谢产物和免疫细胞/试剂作为淋巴液。因此，淋巴系统提供了关键的 用于从所有器官的间隙空间运输流体、大分子、细胞和其他元素的连接 通过淋巴结到达静脉血在完成这一运输过程中，它调节体液量， 大分子稳态、免疫功能、炎症和脂质吸收/代谢。它是一种专门的 具有低压血管的复杂网络的血管系统，具有独特的形成和运输机制 淋巴管淋巴系统既是一个复杂的淋巴管网络，又是一系列独特的淋巴系统。 产生和调节淋巴液流动的内在淋巴泵，驱动其所有功能。由于其 由于其独特、复杂的结构和功能特点，一直难以对其结构进行考察和量化 并在体内发挥作用。然而，更好地了解其结构和功能对健康和 疾病其他国际/国家淋巴生物学会议，包括以前的淋巴论坛 2017年主要关注胚胎发育、淋巴管生成、淋巴管内皮细胞 与癌症和免疫的关系。本申请中概述的会议计划是独一无二的， 这是第一个有一个显着的重点定量方面的主要功能的淋巴 血管系统-淋巴运输。它特别关注淋巴管的复杂方面， 系统，例如;淋巴发育的生物力学、结构和功能、淋巴生长和 病理状态下的重塑，淋巴流生成和调节的机制，最常见的 独特的淋巴细胞-淋巴肌，复杂淋巴结构的定量/计算分析 和功能/流动以及炎症与淋巴和免疫系统之间的关系。因此，在本发明中， 淋巴系统是影响健康的心血管系统的内在的、未充分研究的部分， 这次会议与NHLBI和NIBIB的使命有关。此外，会议还 特别设计，使受训人员和年轻调查员发挥重要作用。

Summary/Abstract The Lymphatic Forum 2019 is the 2nd in a planned conference series that bring together researchers from around the world that study lymphatics in health and disease. The lymphatic vascular system is a relatively understudied, yet vital component of the cardiovascular system that couples the tissue parenchyma to the venous blood via lymph flow through a complex network of lymphatic vessels. It transports fluid, macromolecules, lipids, tissue catabolic products and immune cells/agents as lymph. Thus, the lymphatic system provides critical links for the transport of fluid, macromolecules, cells and other elements from the interstitial space of all organs to and through the lymph nodes to the venous blood. In completing this transport, it regulates body fluid volume, macromolecular homeostasis, immune function, inflammation and lipid absorption/metabolism. It is a specialized vascular system with a complex network of low pressure vessels with unique mechanisms to form and transport lymph. The lymphatic system serves as both a complex network of lymph conduits and as a series of unique intrinsic lymph pumps that generate and regulate the lymph flow that drives all of its functions. Because of its unique, complex structural and functional characteristics, it has been difficult to examine and quantify its structure and function in the body. However a better understanding of its structure and function is important to health and disease. Other international/national lymphatic biology conferences, including the previous Lymphatic Forum 2017 focused predominantly on the embryologic development, lymphangiogenesis, lymphatic endothelial cell function and relationships to cancer and immunity. The conference plan outlined in this application is unique in that it is the first that has a significant focus on quantitative aspects of the principal function of the lymphatic vascular system –lymph transport. It pays particular attention to the complex aspects of lymphatic vascular system such as; biomechanics of lymphatic development, structure and function, lymphatic growth and remodeling in pathological states, the mechanisms of lymph flow generation and regulation, the most common & unique lymphatic cell- lymphatic muscle, quantitative/computational analyses of complex lymphatic structures and function/flow and the relationships between the inflammation & the lymphatic and immune systems. Thus, the lymphatic system is an intrinsic, understudied part of the cardiovascular system that influences health and disease and this conference is relevant to the missions of the NHLBI and NIBIB. Additionally, the conference is specifically designed such that trainees and young investigators have significant roles.