Nutrition, Biostatistics & Bioinformatics Training Grant

项目摘要/摘要 这是一个继续提案，它将使我们从R25T机制(即不再 存在)到T32机制。我们在这个延续方案中的目标是训练统计和 注重计算的个人(生物统计学家、统计学家、工程师、计算机 科学家等)在多学科环境中发挥独立研究人员的作用 专注于癌症研究，受过营养和基础知识培训的研究人员 癌症。为了实现这一目标，我们组建了一个专门从事生物统计/统计的团队， 生物信息学、营养学和癌症的多方面。截至2016年1月1日，26个职位- 博士生已完成该项目，1名将被录取。我们刻意 由于不确定是否继续提供资金，减少了受训人员的人数。 该计划有以下几个重要方面。 1)培训完全是多学科的。 A)我们专注于训练以统计和计算为导向的生物学个人 营养与癌症的研究，创造了了解潜在的 营养与癌症关系中的作用机制。是这样的 理解将允许我们的受训人员在最高级别上为设计和 分析该地区的实验，并真正开发微调的统计方法 适用于实验数据。 B)学习的统计和计算方法通常不会是正式的 课程，但因为它们来自营养实验室的实验数据。 C)培训将包括通过3个实验室的初始轮换；与德克萨斯州的轮换 A&M基因组学设施定量生物学核心，联席主管是饮食 我们培训计划中的化学预防癌症生物学家；轮流通过新的 创建了代谢组学设施，其主任是我们培训计划的导师； 然后在一个实验室进行长期的高强度培训。 2)每名学员将至少有两名导师。 A)营养学家或癌症研究专家，其研究重点是癌症病因学 和预防。学员将被期望成为生物学家的正式成员 实验室，包括在实验室中花费大量时间，参加实验室 为研究生和博士后研究人员提供会议、咨询 实验室，监督实验数据的分析，并最终提出新的 问题和方法。 B)生物统计学家或其他注重计算的个人。我们的团队包括专家 在分析营养与癌症的实验数据时，尤其是那些 纵向的；高通量表达数据的分析； 蛋白质组学数据；基因调控网络的构建和控制等。 3)首席调查员(生物统计学家Raymond J.Carroll博士)将继续 把他相当一部分的时间投入到这个项目上。我们还指定了一个 营养学家(南希·特纳博士)她将继续把她的很大一部分 协调营养培训的时间。 4)研究导师将他们的努力集中在癌症研究上，并获得了他们的初级 来自国家癌症研究所、国家科学基金会的研究资金， 国防部乳腺癌研究计划，美国国家航空和航天管理局 航天局辐射生物学计划和美国癌症研究所 研究。 博士后培训至少为期两年，在某些情况下，这可能是 延长到三年。 6)在稳定状态下，任何时候将有4名学员，与R25T中的人数相同 程序。

Project Summary/Abstract This is a continuation proposal that will transition us from the R25T mechanism (that no longer exists) to the T32 mechanism. Our goal in this continuation proposal is to train statistically and computationally oriented individuals (Biostatisticians, Statisticians, Engineers, Computer Scientists, etc.) to function as independent researchers in a multidisciplinary environment focusing on cancer research, researchers who are trained in the fundamentals of Nutrition and Cancer. To achieve this goal we have assembled a team specializing in Biostatistics/Statistics, Bioinformatics, Nutrition and multiple aspects of Cancer. As of January 1, 2016, 26 post- doctoral trainees have completed the program and 1 will be enrolled. We have deliberately reduced the number of trainees due to the uncertainty about continued funding. The Program has the following important aspects. 1) The training is fully multidisciplinary. a) We focus on training statistically and computationally oriented individuals in the biology of Nutrition and Cancer, creating researchers who understand the underlying mechanisms of action in the relationship between Nutrition and Cancer. Such understanding will allow our trainees to contribute at the highest level to the design and analysis of experiments in the area, and to develop fine-tuned statistical methods truly appropriate for the experimental data. b) The statistical and computational methods learned will not typically be from formal courses, but as they arise from experimental data in nutrition laboratories. c) The training will include initial rotations through 3 laboratories; a rotation with the Texas A&M Genomics Facility Quantitative Biology Core, the co-director of which is a diet chemoprevention cancer biologist in our training program; a rotation through the newly created metabolomics facility, the director of which is a mentor in our training program; followed by intensive long-term training in a single laboratory. 2) Each trainee will have at least two mentors. a) A Nutritionist or Cancer research specialist whose research focuses on cancer etiology and prevention. The trainee will be expected to become a full member of the biologist's laboratory, including spending significant time in the laboratory, attending laboratory meetings, consulting for the graduate students and postdoctoral researchers in the laboratory, supervising the analysis of experimental data and eventually posing new problems and approaches. b) A Biostatistician or other computationally oriented individual. Our team includes experts in the analysis of experimental data arising from Nutrition and Cancer, particularly those of a longitudinal nature; the analysis of high throughput expression data; the analysis of proteomics data; the construction and the control of gene regulatory networks, etc. 3) The Principal Investigator (Raymond J. Carroll, Ph.D., a Biostatistician) will continue to devote a significant fraction of his time to the Program. We have also designated a Nutritionist (Nancy Turner, Ph.D.) who will continue to devote a significant fraction of her time in coordinating the Nutrition training. 4) The research mentors focus their efforts on cancer research, and receive their primary research funding from the National Cancer Institute, the National Science Foundation, Department of Defense Breast Cancer Research Program, the National Aeronautics and Space Administration Radiation Biology Program, and the American Institute for Cancer Research. 5) The postdoctoral training is for a minimum of two full years, and in some cases this can be extended to three years. 6) At steady state there will be 4 trainees at any one time, the same number as in the R25T program.