HEAL Initiative: Coordinating Center to Support NIDA Preventing Opioid Use Disorder in Older Adolescents and Young Adults

项目总结/摘要 虽然已经确定了许多循证干预措施来解决 阿片类药物在美国的流行，更少的进展已经朝着防止启动 阿片类药物滥用和阿片类药物使用障碍（OUD）的发展。认识到迫切需要填补这一 在知识的差距，国家药物滥用研究所（NIDA）正在推出治疗预防阿片类药物 滥用和阿片类药物使用障碍在老年青少年和年轻人的倡议。十个研究项目 (RPs)，一个协调中心（CC），指导委员会（SC），NIDA和其他联邦工作人员将 合作评估针对大龄青少年的循证预防和干预服务， 不同环境和人群中的年轻人。我们认识到，这一重要而复杂的 奋进需要在多地点联合体固有的一系列活动中进行出色的协调。 我们建议设立协调中心，以促进跨地盘活动，并为医管局提供中央支援 预防协作组织。我们的CC有五个具体目标。我们将提供集中的运营， 行政和后勤基础设施，以促进企业集团的协调和沟通（目标1）。 我们将提供实施科学专业知识，以了解证据的交付和适应- 在不同的方案背景下采取基于基础的干预措施（目标2）。我们将建立基础设施， 跨站点数据收集、管理、协调和数据共享（目标3）。我们将提供专家 方法和统计咨询（目标4）。我们将进行严格的经济评估， 决策者在选择产生最大影响的预防战略方面的作用（目标5）。 我们的CC团队由多位首席研究员领导-菲利普格雷厄姆和凯文康威博士-他们是 多中心研究的经验丰富的领导者和共识建立、数据协调、项目 评估和成瘾病因学。由核心领导者、主要员工和顾问组成的更广泛的团队带来了 强大的科学和实施科学技能与对阿片类药物危机的深刻理解交织在一起， 预防科学，以及阿片类药物滥用和成瘾的经济学。我们提供经过验证的计算 基础设施和统计专业知识，以支持所有必要的数据管理和分析需求， 财团。我们以RTI无与伦比的经验和专业知识为后盾， 领导其他40多个CC，以确保我们支持和实现目标。总的来说， 充分准备将预防科学概念应用于国家应对阿片类药物危机的方法。

PROJECT SUMMARY/ABSTRACT Although many evidence-based interventions have been identified to address the consequences of the opioid epidemic in the United States, much less progress has made been toward preventing the initiation of opioid misuse and the development of opioid use disorder (OUD). Recognizing the urgent need to fill this gap in knowledge, the National Institute on Drug Abuse (NIDA) is launching the HEAL Preventing Opioid Misuse and Opioid Use Disorder in Older Adolescents and Young Adults Initiative. Ten research projects (RPs), one coordinating center (CC), the steering committee (SC), and NIDA and other federal staff will collaborate to evaluate evidence-based prevention and intervention services for older adolescents and young adults across diverse settings and populations. We recognize that this important and complex endeavor requires exceptional coordination across a range of activities inherent to multi-site consortia. We propose a CC to facilitate cross-site activities and provide centralized support for the HEAL Prevention Collaborative (HPC). Our CC has five Specific Aims. We will provide centralized operational, administrative, and logistical infrastructure to facilitate consortium coordination and communication (Aim 1). We will provide implementation science expertise to understand the delivery and adaptation of evidence- based interventions within different programmatic settings (Aim 2). We will establish an infrastructure for cross-site data collection, management, harmonization, and data sharing (Aim 3). We will provide expert methodological and statistical consultation (Aim 4). We will conduct rigorous economic evaluation to guide decisionmakers in choosing prevention strategies that produce the greatest impact (Aim 5). Our CC team is led by multiple Principal Investigators—Drs. Phillip Graham and Kevin Conway—who are experienced leaders of multi-site studies and experts in consensus building, data harmonization, program evaluation, and addiction etiology. The broader team of Core leaders, key staff, and consultants brings robust scientific and implementation science skills interwoven with a deep understanding of the opioid crisis, prevention science, and the economics of opioid misuse and addiction. We offer proven computational infrastructure and statistical expertise to support all the required data management and analysis needs for the consortium. We are backed by RTI's unsurpassed experience and proficiency—born from successful leadership of over 40 other CCs—to ensure that we support and accomplish the aims. Collectively, we are well-prepared to apply prevention science concepts to the Nation's approach to the opioid crisis.