Malaria in pregnancy: exposure, immunity and complications

加大疟疾控制力度可能会导致缺乏发展免疫力所需的暴露。我们将使用来自非洲、巴布亚新几内亚和亚洲的血浆样本以及我们开发的免疫指标，来发现(1)哪些是最重要的保护性免疫反应，(2)这些反应是如何受到暴露变化或新药的影响的。总体而言，我们希望确定保护性免疫的标记，可以用来识别怀孕期间疟疾及其并发症的最高风险的妇女。

Increasing malaria control efforts may lead to lack of exposure needed to develop immunity. We will use plasma samples from Africa, PNG and Asia, and measures of immunity we have developed, to discover (1) which are the most important protective immune responses and (2) how are these affected by changing exposure or new drugs. Overall, we hope to identify markers of protective immunity that can be used to identify women at most risk of malaria in pregnancy and its complications