Mammalian "endotoxin": Characterisation of highly inflammatory endogenous material

炎症驱动许多常见疾病的发展，包括心脏病、癌症、阿尔茨海默病和糖尿病。我们了解细菌分子如何在感染期间引发炎症，但促进衰老退行性疾病的炎症刺激的性质一直难以捉摸。在这个项目中，我们将识别在压力下细胞中发生改变的高度炎症分子。对这些途径的了解将促进慢性病的新治疗。

Inflammation drives development of many common diseases including heart disease, cancer, Alzheimer's disease and diabetes. We understand how bacterial molecules initiate inflammation during infections, but the nature of inflammatory stimuli that promote degenerative diseases of ageing has been elusive. In this project we will identify highly inflammatory molecules that have become altered in cells under stress. Knowledge of these pathways will promote new treatments for chronic diseases.