Advanced Microscopy Facility

高级显微镜设备--项目摘要/摘要 先进显微镜设备(AMF)是矩阵癌症中心的共享资源，在 研究核心管理办公室的赞助，这是弗吉尼亚大学的一个系 UVA医学院(SOM)。自1987年第一笔癌症中心支持拨款给弗吉尼亚大学以来，AMF已经 为癌症中心的研究人员提供了独特的访问仪器和服务的可视化 生物过程和结构。因为显微镜已经成为一种不可或缺的几乎通用的工具 生物医学研究，AMF的尖端显微镜设备使癌症中心 成员们在癌症的病因、扩散和治疗方面做出重要发现。 AMF的主要使命是服务于成像需求并使特殊的癌症研究在 弗吉尼亚大学。具体的目标是提供住房和提供负担得起的最先进的通道 显微镜仪器和高质量的成像服务，使癌症中心的研究人员能够 实践和成像科学，并建立了AMF用户之间的协作纽带。 该设施既是一个全面服务的设施，也是一个用户设施，已经从主要的电子设施扩展到 显微镜中心现在涵盖了全方位的光学和电子显微镜技术。最高统帅有 继续支持AMF，并自上次CCSG审查以来进行了大量投资(约7美元 百万美元)，以建立冷冻显微镜服务。来自NIH的机构支持和资金共享 仪器赠款使AMF获得了一系列令人印象深刻的最先进的显微镜， 包括三个具有超分辨率或双光子成像能力的共焦显微镜和一个300千伏 泰坦克里奥斯透射式电子显微镜配有直接电子探测器，仅在 少数几家北美机构。为癌症中心成员提供使用电子冷冻的途径- 显微镜服务是AMF能力的一大进步。该设施于#年被评为“卓越”。 最后一篇评论。AMF工作人员致力于进一步增强共享资源的能力，以 为癌症中心的研究人员提供卓越的服务。

ADVANCED MICROSCOPY FACILITY – PROJECT SUMMARY/ABSTRACT The Advanced Microscopy Facility (AMF) is a matrix Cancer Center shared resource, which operates under the auspices of the Office of Research Core Administration, a department within the University of Virginia (UVA) School of Medicine (SOM). Since the first Cancer Center Support Grant to UVA in 1987, the AMF has provided Cancer Center investigators with unique access to instrumentation and services for visualization of biological processes and structures. As microscopy has become an indispensable and near universal tool for biomedical research, access to cutting edge microscopy equipment at the AMF has allowed Cancer Center members to make important discoveries regarding the cause, spread, and treatment of cancer. The AMF's primary mission is to serve the imaging needs and enable the exceptional cancer research at the University of Virginia. The specific aims are to house and provide affordable access to state-of-the-art microscopy instrumentation and high-quality imaging services, empower Cancer Center investigators in the practice and science of imaging, and built a nexus for collaboration among the AMF users. The facility, which is both a full-service and a user-facility, has been expanded from primarily an electron microscopy center to now encompass a full range of light and electron microscopy technologies. The SOM has continued to support the AMF and since the last CCSG review and has made substantial investment (~$7 million) to establish the cryo-microscopy services. The institutional support and funds from NIH shared instrumentation grants have allowed the AMF to acquire an impressive array of state-of-the-art microscopes, including three confocal microscopes with super-resolution or two-photon imaging capabilities, and a 300 kV Titan Krios transmission electron microscope equipped with a direct electron detector, available at only a handful North American institutions. Providing Cancer Center members with access to electron cryo- microscopy services is a major advancement of the AMF's capabilities. The facility was rated “outstanding” in the last review. The AMF staff have worked to further enhance the capabilities of the shared resource to provide exceptional services to Cancer Center researchers.