IGF::OT::IGF: Base Award for Using Rodent Behavioral Models to Identify Substance Abuse Pharmacotherapies

该合同的目的是提供以下啮齿动物体内试验的测试能力： 活性、大鼠药物辨别、小鼠条件性位置偏爱和大鼠自我给药。这些模型 这是一个更大的临床前测试层次结构的一部分，由单独的合同支持，这些合同为化合物的评估提供资金， 大鼠颅内自我刺激试验，各种药物寻求行为复发模型，以及灵长类动物 药物歧视和自我管理模式。

The purpose of this contract will be to provide testing capacity in the following rodent in vivo assays: mouse locomotor activity, rat drug discrimination, mouse conditioned place preference, and rat self-administration. These models are part of a larger pre-clinical testing hierarchy supported by separate contracts that fund the evaluation of compounds in the rat intracranial self-stimulation assay, various models of relapse to drug-seeking behavior, as well as the primate drug discrimination and self-administration models.