Core Grant for Vision Research

总结/摘要-总体 继续寻求密歇根大学视觉研究核心补助金的支持。支持 要求五个模块：1）电子和计算机模块，用于设计和建造新的 电子设备，为研究计算机及其与实验室的接口提供帮助 仪器，并维修现有的电子设备，配备电子工程师; 2）功能 用于活体眼部结构成像和眼功能评估的评估模块 实验室动物，由技术人员组成; 3）仪器车间模块，用于设计和构建 机械仪器和修改或修理现有仪器，配备仪器 4）分子生物学模块，用于提供对分子生物学所需的仪器的访问 以及协助分析微阵列和生物信息学数据，由一名统计遗传学家工作; 以及5）形态学和成像模块，用于提供对最先进的设备和专家的访问 眼组织处理、显微镜检查（光、宽场荧光和共聚焦）和成像人员 分析，由技术人员组成。 密歇根大学视觉研究中心的具体目标是加强研究 视觉科学家的环境，促进视觉系统及其疾病的合作研究， 扩大在这个校园的视觉研究，使非视觉科学家的技能和观点承担 研究视觉系统。 31名参与研究者目前持有11项NEI R 01赠款和2项NEI K 08赠款。的 这些研究者的研究兴趣是多样的，包括电生理学，神经生物学，生物化学， 分子生物学、分子遗传学、发育生物学、生物统计学、免疫学和临床 眼科视觉研究中心位于W.K.凯洛格眼科中心，一个30万平方米。英尺 建筑群包含专用于每个模块的空间，加上最先进的基础设施 和临床研究。密歇根大学眼科和视觉科学系 提供大量额外资源，支持促进视觉研究的共同目标。

SUMMARY/ABSTRACT - OVERALL Continued support is sought for the Core Grant for Vision Research at the University of Michigan. Support for five Modules is requested: 1) an Electronics and Computer Module for designing and constructing novel electronic equipment, providing assistance with research computers and their interfaces with laboratory instruments, and repairing existing electronic equipment, staffed by an electronics engineer; 2) a Functional Assessment Module for the imaging of ocular structures and the evaluation of ocular function in living laboratory animals, staffed by a technician; 3) an Instrument Shop Module for designing and constructing mechanical instrumentation and modifying or repairing existing instrumentation, staffed by an instrument maker; 4) a Molecular Biology Module for providing access to instrumentation necessary for molecular biology as well assistance with the analysis of microarray and bioinformatics data, staffed by a statistical geneticist; and 5) a Morphology and Imaging Module for providing access to state-of-the-art equipment and expert personnel for ocular tissue processing, microscopy (light, wide-field fluorescence, and confocal), and image analysis, staffed by a technician. The specific aims of the Vision Research Core at the University of Michigan are to enhance the research environment for vision scientists, facilitate collaborative studies of the visual system and its diseases, and expand vision research on this campus to bring the skills and perspectives of non-vision scientists to bear upon research on the visual system. The 31 participating investigators currently hold 11 NEI R01 grants as well as 2 NEI K08 grants. The research interests of these investigators are diverse and include electrophysiology, neurobiology, biochemistry, molecular biology, molecular genetics, developmental biology, biostatistics, immunology, and clinical ophthalmology. The Vision Research Core is housed within the W.K. Kellogg Eye Center, a 300,000 sq. ft. building complex containing space dedicated to each of the modules, plus state-of-the-art facilities for basic and clinical research. The Department of Ophthalmology and Visual Sciences and the University of Michigan provide substantial additional resources that support the shared goal of fostering vision research.