Drug Releasing Microdiscs for Esophageal Drug Delivery

项目总结： 嗜酸性食管炎(EoE)是一种影响儿童食道炎的炎症性疾病。 导致不健康、食道狭窄和需要长期治疗的比率增加 医疗保健。标签外使用局部类固醇是主要的治疗方法，但失败率很高。 临床上对适口性的担忧使得医生有必要使用未经研究的食品 作为赋形剂。这项建议的目标是调查当前经验的属性 并利用这些知识开发一种微型聚合物圆盘(微盘) 目的：提高药物在食道内的滞留时间。微盘的设计是为了延长 药物在食道中的滞留时间和具有控释性能的增加 粘膜暴露于药物，从而将药物直接输送到EoE的靶点。经久不衰 粘附性圆盘的停留时间有望提高生物利用度 减少患者对类固醇的暴露，降低成本，并为其他 副作用较少的药物治疗将以同样的方式提供。

PROJECT SUMMARY: Eosinophilic esophagitis (EoE) is an inflammatory disease affecting children at an increasing rate leading to failure to thrive, esophageal stricturing, and the need for long term healthcare. Off-label use of topical steroids is the mainstay of treatment, but a high failure rate and clinical concerns of palatability have necessitated physicians using unstudied grocery items as excipients. The goal of this proposal is to investigate the properties of current empiric therapies and use that knowledge to develop a microscale polymer disc (microdiscs) designed to improve residence time of drug therapy in the esophagus. Microdiscs are designed to prolong drug residence time in the esophagus and have controlled-release properties to increase mucosal exposure to drug, thus delivering drug directly to the target site of EoE. The prolonged residence time of the mucoadhesive discs will be expected to improve bioavailability which decreases patient exposure to steroids, decreases costs, and opens new possibilities for other pharmaceutical treatments with fewer side effects to be delivered in the same manner.