The Early Detection Research Network: Data Management and Coordinating Center

 早期检测研究网络（EDRN）成功的关键在于多学科科学家之间的良好沟通;有效评估和优先考虑有前途的生物标志物;以及严格的验证研究，以证明其临床实用性。数据管理和协调中心（DMCC）更新的总体目标是（i）提供EDRN的协调，以加强EDRN研究人员之间以及与一般科学界的沟通和合作;（ii）协调EDRN验证研究;（iii）向更广泛的科学界和公众传播癌症生物标志物信息;以及（iv）管理EDRN核心基金。在EDRN指导委员会的指导下，DMCC将1）通过为EDRN会议和研讨会提供支持，开发和维护EDRN安全网站和邮件列表服务器，制作和维护所有EDRN文件，以及维护EDRN申请的在线审查系统，进行网络协调并促进科学研究人员之间的合作; 2）通过开发和维护验证研究数据管理系统支持EDRN验证研究;与EDRN研究者合作进行研究设计、方案开发、数据表和研究手册;协调和监测研究;跟踪标本;并进行QA/QC和研究评估; 3）与NCI和JPL合作，为EDRN安全网站提供信息学资源，用于数据安全、数据仓库和数据共享，以及公共网站进行传播;和4）与EDRN SC和NCI项目协调员和FHCRC OSR密切合作，在EDRN SC批准后及时启动核心资金，并确保符合子奖项管理的所有监管要求。

 DESCRIPTION (provided by applicant): The key for the Early Detection Research Network (EDRN)'s success lies in good communication among scientists in multiple disciplines; efficient evaluation and prioritization of promising biomarkers; and rigorous validation studies to demonstrate their clinical utility. The overall aims of the proposed renewal of the Data Management and Coordinating Center (DMCC) are to (i) provide coordination of EDRN in order to enhance communication and collaboration among EDRN investigators and with general scientific communities; (ii) coordinate EDRN validation studies; (iii) disseminate cancer biomarker information to broader scientific communities and the public; and (iv) mange the EDRN Core funds. Under the direction of the EDRN Steering Committee, the DMCC will 1) perform network coordination and promote collaborations among scientific investigators by providing support for EDRN meetings and workshops, developing and maintaining EDRN secure websites and listservs, producing and maintaining all EDRN documents, and maintaining the online review system for applications submitted to the EDRN; 2) support EDRN validation studies by developing and maintaining validation study data management systems; working with EDRN investigator on study design, protocol development, data forms, and study manuals; coordinating and monitoring studies; tracking specimens; and performing QA/QC and study evaluation; 3) work with the NCI and JPL to provide informatics resources for the EDRN Secure Web site for data security, data warehousing, and data sharing, and a Public Web site for dissemination; and 4) work closely with the EDRN SC and the NCI Project Coordinator and FHCRC OSR to timely activate the core funds after the EDRN SC approval and ensure the compliance of all regulatory requirements for sub-award management.