2020 Ligand Recognition & Molecular Gating GRC/GRS

摘要：2020年戈登研究会议（GRC）配体识别和分子 Gating将于3月15日至20日在意大利文艺复兴时期的托斯卡纳Il Ciocco度假村举行。GRC将 之前是相关的戈登研究研讨会（GRS），这是由年轻人组织的， 科学家（3月14日至15日）。这个GRC/GRS组合的主题是独特的，因为它解决了 三种重要的膜蛋白的分子机制：离子通道，主动转运蛋白， 和G蛋白偶联受体（GPCR）。这些蛋白质是人体生理学的核心， 功能障碍导致大量神经肌肉、内分泌和代谢疾病。这些蛋白质 是主要的治疗靶点;目前市场上超过50%的药物都是针对它们的。因此，我们认为， 阐明它们的分子机制对于提供新的干预机会至关重要， 最终将改善人类健康。本GRC/GRS的中心焦点是分子 配体识别和结合的机制，配体诱导的构象变化，溶质 运输、功能调节和信号传输。目前的重点是阐明 这些蛋白质以及结构数据如何阐明这些蛋白质的机制和生理作用， proteins.我们对膜蛋白功能的理解正在经历一个重大的飞跃， 多项技术突破，其中最重要的是电子冷冻革命， 显微镜导致确定了人类转运蛋白的几个医学重要结构， 通道和信号复合物，如Na+通道，多药ABC转运蛋白和GPCR/G- 蛋白质复合物在理解对人类健康至关重要的基本过程方面也取得了进展， 这些蛋白质的功能，如主要通道的门控机制，动态重排和 形成不同的信号复合物。努力确定未表征膜的功能 蛋白质家族也在进行中，以了解它们在人类生理学和疾病中的功能。 这个GRC是独一无二的，因为它汇集了科学家谁在这三个不同类别的工作， 膜蛋白，并位于不同的大陆，因此不定期见面。他们将 从这些相互作用中受益匪浅，因为这些膜蛋白具有共同的机制， 原则，可以通过大量的技术进行研究，其中许多技术将在本 会议该计划将有大约40名发言人，在该领域的知名领导人的组合， 年轻的研究人员、博士后和研究生。9场演讲会和几场海报会 将解决转运蛋白，离子通道和GPCR的主要属性。配体上的GRC/GRS 识别和分子门控将为最新的 研究成果和建立新的合作。

SUMMARY: The 2020 Gordon Research Conference (GRC) on Ligand Recognition and Molecular Gating will be held from March 15th-20th at the Renaissance Tuscany Il Ciocco Resort, Italy. The GRC will be preceded by the related Gordon Research Seminar (GRS), which is organized by and for young scientists (March 14th-15th). The topic of this GRC/GRS combination is unique, as it addresses the molecular mechanisms of three important classes of membrane proteins: ion channels, active transporters, and G-protein coupled receptors (GPCRs). These proteins are central to human physiology and their dysfunction leads to a large number of neuromuscular, endocrine and metabolic diseases. These proteins are major therapeutic targets; more than 50% of current drugs on the market target them. Therefore, elucidating their molecular mechanisms is essential to enable new opportunities for intervention, which ultimately will lead to improvement of human health. The central focus of this GRC/GRS is on the molecular mechanisms underlying ligand recognition and binding, ligand-induced conformational changes, solute transport, regulation of function, and signal transmission. Current focus is on elucidating the structures of these proteins and on how the structural data illuminates the mechanisms and physiological roles of these proteins. Our understanding of membrane protein function is undergoing a major leap forward, fueled by multiple technological breakthroughs, the most important of which is the revolution in electron cryo- microscopy that led to the determination of several medically important structures of human transporters, channels and signaling complexes, such as Na+ channels, multidrug ABC transporters and GPCR/G- protein complexes. Progress has also been made in understanding fundamental processes that are key to the function of these proteins, such as gating mechanisms of major channels, dynamic rearrangements and the formation of different signaling complexes. Efforts to identify the function of uncharacterized membrane protein families are also underway to understand their function in human physiology and disease. This GRC is unique as it brings together scientists who work on these three different classes of membrane proteins and are located on different continents, and thus do not meet regularly. They will benefit tremendously from these interactions as these membrane proteins share common mechanistic principles and can be studied by a vast array of techniques, many of which will be represented in this conference. The program will have around 40 speakers, a mix of well-established leaders in the field, young investigators, postdocs and graduate students. Nine speaker sessions and several poster sessions will address the major properties of transporters, ion channels, and GPCRs. The GRC/GRS on Ligand Recognition and Molecular Gating will provide a platform for the presentation and discussion of latest research results and for the establishment of new collaborations.