2020 Cornea and Ocular Surface Biology and Pathology GRC/GRS

项目摘要 视力取决于眼表的完整性和功能性，包括角膜、结膜、 腺体和泪膜。更改此集成单元可能会导致视力受损或失明 发达和发展中世界。了解眼表动态平衡与疾病的基本原理 再加上创新的治疗发展，对老龄化人口的健康和经济至关重要。 我们寻求支持在2020年戈登研究会议上举行的视觉研究世界领导人会议 角膜与眼表生物学与病理学(GRC-COSBP)，2020年2月16日至21日，托斯卡纳文艺复兴 意大利卢卡Il Ciocco。在以往GRC-COSBP成功的基础上，我们计划就关键问题举行9次科学会议 眼表生物学和病理学的范式转换创新。会议将由20分钟的主要会议组成 从海报演示中邀请1-2个简短的讲座，重点是年轻的调查人员，使他们能够 向社会公布他们的发现。会议的题目是：1.内在微生物群及其影响 来自偏远地区的微生物区系；2.健康和患病眼表的外体；3.CRISPR/个性化 角膜营养不良的药物治疗性基因编辑；4.角膜干细胞的鉴定和生成 转录组和蛋白质组学：角膜细胞类型和疾病变化； 6.影响其功能的角膜邻居：结膜、眉板腺和泪腺；7.从发现到 临床：药物测试和监管问题；8.眼表面药物输送的进展：病毒与纳米结构； 9.眼表疾病的炎症与免疫。早期职业科学家与老牌科学家配对 研究人员将共同主持这些会议。我们邀请了一个多元化、性别均衡的36位演讲者 他们的谈话集中在他们未公布的数据上。演讲者包括初级科学家和一些远见之外的人 其重要研究与眼科研究有相似之处并应用于眼科研究的领域。将外部发言人包括在内 将促进跨学科和年轻人之间的讨论和合作机会 该领域的调查人员和领导者。我们要求演讲者在GRC期间留下来。我们还将举办第四届 为期两天的戈登研究研讨会(GRS)，面向在眼表工作的研究生和博士后 紧靠GRC-COSBP之前的字段。GRS促进了早期职业科学家的互动和机会 在轻松的气氛中介绍数据，并在会议组织和主持会议方面积累经验。 以前的GRS参与者继续积极参与GRC，我们完全预计情况会是这样 在2020年。2020 GRS和GRC-COSBP将继续支持未来的现场领导者与 在GRS和GRC的资深科学家之间相互交流。形成的关系可能会持续下去， 多年来保持高效率。我们鼓励代表不足的少数族裔参加GRC和通过GRC参加GRS 奖学金。我们将通过社交媒体让社区了解这一GRC和计划更新。NEI支持 将极大地保证2020年GRC-COSBP的节目质量和最终成功。

Project Summary Vision depends on the integrity and functionality of ocular surface comprising cornea, conjunctiva, associated glands and tear film. Alteration of this integrated unit can result in visual impairment or blindness across the developed and developing world. Understanding the fundamentals of ocular surface homeostasis and disease together with innovative therapeutic developments is vital for the health of aging population and the economy. We seek support for a meeting of world leaders in vision research at the 2020 Gordon Research Conference on Cornea & Ocular Surface Biology & Pathology (GRC-COSBP), February 16-21 2020, the Renaissance Tuscany Il Ciocco, Lucca, Italy. Building on the success of previous GRC-COSBP we plan 9 scientific sessions on key paradigm shifting innovations in ocular surface biology and pathology. Sessions will comprise main 20-minute talks with 1-2 short talks invited from poster presentations and focused on young investigators to enable them to present their findings to the community. The session titles are: 1. Intrinsic microbiome and influences of microbiota from remote sites; 2. Exosomes in healthy and diseased ocular surface; 3. CRISPR/personalized medicine – therapeutic gene editing in corneal dystrophies; 4. Identification and generation of corneal stem cells and their use for transplantation; 5. Transcriptome and proteomics: corneal cell types and changes in disease; 6. Corneal neighbors affecting its function: conjunctiva, meibomian and lacrimal glands; 7. From discovery to clinic: drug testing and regulatory issues; 8. Advances in ocular surface drug delivery: viruses vs. nanoconstructs; and 9. Inflammation and immunity in ocular surface diseases. Early career scientists paired with established researchers will co-moderate the sessions. We are inviting a diverse, gender-balanced selection of 36 speakers focusing their talks on their unpublished data. Speakers include junior scientists and some outside of the vision field whose important studies have parallels and application to eye research. The inclusion of speakers outside of the eye field will foster discussions and collaborative opportunities across disciplines and between young investigators and leaders in the field. We request that speakers stay for the GRC duration. We will also hold 4th two-day Gordon Research Seminar (GRS) for graduate students and postdocs working in the ocular surface field immediately before GRC-COSBP. GRS facilitates interactions and opportunities for early career scientists to present data in a relaxed atmosphere and gain experience in conference organization and chairing sessions. Previous GRS participants have continued active participation in the GRC and we fully expect this to be the case in 2020. 2020 GRS and GRC-COSBP will continue the tradition of supporting future field leaders to interact with each other at the GRS and with established scientists at the GRC. The formed relationships are likely to last and be productive for many years. We encourage underrepresented minorities to attend GRC and GRS through GRC scholarships. We will keep the community aware of this GRC and program updates via social media. NEI support will greatly ensure the program quality and the ultimate success of the 2020 GRC-COSBP.