2019 International EMT Society meeting

摘要 这项建议的具体目的是为下列活动的费用（旅费和住宿费）获得部分资金： 来自美国的初级研究员、博士后研究员和研究生参加第九届 上皮-间充质转化国际会议。会议将于11月11日至 2019年14月14日在日本熊本熊本大学百年纪念馆举行。 Epithelial-Mesenchymal Transition International Association（TEMTIA） 会议的目标是1。将不同学科的调查人员聚集在一起， 癌症，病理学和发展，讨论他们对EMT的观察，并探讨是否有 是对这一进程的重要组成部分达成共识。2.提供一个论坛，让学生和 初级调查员可以与高级调查员互动，并在 领域3.扩大EMT相关研究人员的可行合作跨学科论坛 化国际大这将继续提供一个全球性的网络， 和跨学科的技术。4.及时发布关于细胞、分子和 在适当的跨学科国际期刊上发表EMT的遗传方面。 上皮-间充质转化（EMT）是由上皮细胞中的细胞进行的基本细胞过程。 胚胎从细胞片形成三维结构。在EMT过程中，上皮细胞 粘附于邻近细胞，降解局部基底膜并侵入下层细胞。 间质细胞外基质在细胞水平，这一过程需要特定的信号转导 元件、新基因转录、细胞骨架重组、细胞外基质分泌 分子和生长因子。在胚胎中，这一过程在原肠胚形成、神经嵴 细胞形成，体节分解，胰岛形成，心脏瓣膜形成脑组织 以及器官形成的其他几个领域。在成人中，EMT作为伤口的一个组成部分发生， 愈合以及癌症转移和组织纤维化的病理学中。

Abstract The specific aim of this proposal is to obtain partial funding for the expenses (travel and lodging) for junior investigators, postdoctoral fellows and graduate students from the USA to attend the 9th International Meeting on Epithelial-Mesenchymal Transition. The meeting will be held November 11- 14, 2019 in the Centennial Memorial Hall at University of Kumamoto, Kumamoto, Japan under the auspices of the Epithelial-Mesenchymal Transition International Association (TEMTIA). The objectives of the meeting are to 1. Bring together investigators in the separate disciplines of cancer, pathology and development to discuss their observations on EMT and explore whether there is a consensus on important components of the process. 2. Provide a forum where students and junior investigators can interact with senior investigators and display their own work and ideas in the field. 3. Expand a viable co-operative crossdisciplinary forum of EMT-related researchers internationally. This will continue to provide a worldwide network for exchange of expertise, reagents and techniques across disciplines. 4. Publish a timely meeting update on cellular, molecular and genetic aspects of EMT in an appropriate cross-disciplinary international journal. Epithelial-mesenchymal transition (EMT) is a fundamental cellular process undertaken by cells in the embryo to form 3-dimensional structures from sheets of cells. During EMT, epithelial cells lose adherence to adjacent cells, degrade the local basement membrane and invade the underlying interstitial extracellular matrix. At the cellular level, this process requires specific signal transduction elements, new gene transcription, reorganization of the cytoskeleton, secretion of extracellular matrix molecules and growth factors. In the embryo, this process is reiterated at gastrulation, neural crest cell formation, somite breakdown, pancreatic islet formation, heart valve formation brain organization and in several other areas of organogenesis. In the adult, EMT occurs as a component of wound healing and in the pathologies of cancer metastasis and tissue fibrosis.