DISCOVERY - Administrative Core

摘要（管理核心） DISCOVERY行政核心将确保这一独特的科学和计划的成功。 复杂和大规模的项目，作为业务和组织的基础设施， 探索研究和网络。作为网络的管理和通信枢纽， 管理核心将确保网络核心、团队、小组委员会和研究中心同步工作， 研究和实现总体目标。行政核心将提供杰出的科学领导 和最先进的管理基础设施。建议的具体强度 DISCOVERY行政核心包括（1）MGH团队的全方位领导经验 研究人员和临床研究管理专业人员在复杂的合作项目，包括多， 中心卒中试验专业知识;（2）在拟议研究的各个方面的科学领导;（3）机构支持 以及获得现有NIH资助的资源，包括大型国家网络协调方面的专业知识 （MarkVCID，NeuroNEXT）和临床数据管理系统（NeuroBank）;（4）已建立的跟踪记录 DISCOVERY网络领导层与其他核心领导层之间的协作，以及 参与拟定研究的人员和研究者。如果选中，DISCOVERY管理核心将 在科学和管理上领导DISCOVERY网络成功执行的理想位置 这项重要而又高度复杂的中风后认知障碍和痴呆症的研究。

ABSTRACT (ADMINISTRATIVE CORE) The DISCOVERY Administrative Core will ensure the scientific and programmatic success of this uniquely complex and large-scale project by serving as the operational and organizational infrastructure for the DISCOVERY study and network. Serving as the management and communication hub of the network, the Administrative Core will ensure network cores, teams, subcommittees and sites work in synchronicity to execute the study and achieve the overall aims. The Administrative Core will provide outstanding scientific leadership and state-of-the-art administrative infrastructure to the DISCOVERY Network. Specific strengths of the proposed DISCOVERY Administrative Core include (1) the full range of leadership experience of the MGH team investigators and clinical research management professionals in complex collaborative projects including multi- center stroke trial expertise; (2) scientific leadership in all aspects of the proposed study; (3) institutional support and access to the existing NIH-funded resources including expertise in large national network coordination (MarkVCID, NeuroNEXT) and clinical data management systems (NeuroBank); (4) the established track record of collaboration between the DISCOVERY Network leadership and the other Core Leads as well as the key personnel and investigators in the proposed study. If selected, the DISCOVERY Administrative Core will be ideally positioned to scientifically and administratively lead the DISCOVERY Network in the successful execution of this important and highly complex post stroke cognitive impairment and dementia study.