Core A

核心A(管理核心)是一个大型核心，由不同的管理子组组成 人力、物力资源和数据分析/数据库建设。实现高效、集中的运营 整个中心，我们在核心A PI的领导下集成了这些不同的组件，他还 担任中心主任。这个核心有三个主要目标：行政领导、组织 人力生物资源和数据组织/数据库维护。在目标1中，这一核心将领导金融 管理、组织人类和动物主题协议以及协调研究会议 和这个中心内的年度静修。该核心将通过以下方式为整个中心提供科学领导 在中心内部集中组织科学问题以得出统一的结论，并进行协调 与中心外的调查人员进行合作研究和材料交流。此核心将维护 P50孔德中心的网页，组织教育和外展计划。最后，这一核心将引领 注重研究的严密性和完整性，并确保成员遵守数据/资源共享政策。 在目标2中，这个核心将组织并为中心调查人员提供几种类型的已建立的人类 资源，包括用于遗传研究的三个病例对照样本集，来自 人类大脑，来自两个预期队列样本的血液，以及人类诱导的多能干细胞。在AIM 3.本核心将继续开发一个数据库，其中包括在项目中获得的多种类型的数据 将被系统地存储，以支持调查人员共享、分析和保存数据。这也是一个 为科学界内的数据和资源共享以及公众宣传奠定了基础。总而言之， 我相信这个核心将继续发挥关键作用，为行政管理提供中央服务 协调、组织人力生物资源以及数据管理/数据库维护。这个核心 将代表该中心领导研究的严谨性和完整性。我们将强调教育和公众 外联计划，根据我们在目前的P50中制定的成功的议定书。

The Core A (Administrative Core) is a large core that comprises sub-groups of administration, distinct resources of human materials, and data analyses/database construction. For efficient and central operation of the overall center, we have integrated these distinct components under the leadership of Core A PI, who also serves as the center director. This Core has three major aims: administrative leadership, organization of human bio-resources, and data organization/database maintenance. In Aim 1, this Core will lead financial administration, organization of human and animal subject protocols, and coordination of research meetings and annual retreat inside this Center. This Core will provide scientific leadership to the entire Center by centrally organizing scientific issues towards uniform conclusions inside the Center, and coordinating collaborative research and material exchange with investigators outside the Center. This Core will maintain the web page of the P50 Conte center, organize education and outreach plans. Lastly, this Core will lead the Center in research rigor and integrity and make sure the members to observe data/resource sharing policies. In Aim 2, this Core will organize and provide the center investigators with several types of established human resources, including three case-control sample sets for genetic study, the datasets of RNA-sequencing from human brains, blood from two prospective cohort samples, and human induced pluripotent stem cells. In Aim 3, this Core will continue development of a database in which the multiple types of data obtained in Projects will be systematically stored to support investigators for data sharing, analysis, and preservation. This is also a basis of data and resource sharing within the scientific community as well as public outreach. In summary, believe that this Core will continuously play a key role by providing the central service in administrative coordination, organization of human bio-resources, and data management/database maintenance. This core will lead research rigor and integrity on behalf of the Center. We will emphasize educational and public outreach plans, according to the successful protocol that we have built in the current P50.