Stanford Training Program in Lung Biology

 描述（由申请人提供）：在过去的十年中，医生科学家的人口统计数据严重倾斜，NIH资助的60多岁和70多岁的主要研究者的比例飙升，年轻的医生科学家显着下降。这种转变在程序性学科中尤其明显，如肺部和重症监护医学，利润丰厚的临床实践吸引了有才华的医生，他们在另一个时代会进入学术医学。在斯坦福大学，我们寻求扭转这一趋势，鼓励个人进入发现为基础的职业生涯，通过接触到一个新的和动态的科学愿景，由辉煌的新技术在这里和邻近的硅谷新兴。这个新的斯坦福大学T32培训资助计划结合了成人和儿科肺计划，以选择最有前途的学员，并提供最佳的多元化跨学科培训经验。马克尼科尔斯博士，成人主任和大卫康菲尔德博士，儿科主任，将分享项目主任的责任，每个人都带来了独特的和互补的技能，领导地位。我们从斯坦福大学生物医学界仔细筛选了30位导师，他们在培训和学术生产力方面有着良好的记录。根据导师的专业知识，我们确定了八个卓越领域，学员可以从中选择一个个性化发展计划的主要重点。这些研究领域包括：1）血管疾病，2）干细胞和肺发育，3）遗传学和基因组学，4）肺损伤和修复，5）肺微生物组，6）肺癌和7）结果研究，以及8）成像。拨款提案概述了一个过程，通过这个过程，斯坦福大学的肺部/重症监护研究员接触到研究领域，介绍给导师，并通过一个选择性的过程，旨在确定学员在学术医学上取得成功的最佳机会。我们描述了一个得到良好支持和精心构建的监督系统，以促进招聘代表性不足的少数民族。所有T32学员将有一个个性化的发展计划，其中包括核心课程和选修适合他们的研究领域。通过由PD领导的纵向双月T32会议和与T32学员，导师和PD的季度非正式会议，学员将沉浸在学术肺医学的微观文化中。一个科学监督委员会将确定适当的课程，并确保持续和及时的培训生进展。我们在斯坦福大学组建了一个经验丰富的内部咨询委员会，并为外部咨询委员会组建了一个与斯坦福大学关系密切的知名团体。我们将利用这些团体，导师和学员的定期反馈，以确定方案的优势和弱点，并重新评估我们的流程，以调整，适应和改进T32奖学金。在承认留住学术医学医生的固有挑战的同时，斯坦福大学特别准备好捕捉，发展和激励下一代的医生科学家和临床研究人员。

 DESCRIPTION (provided by applicant): The demographics of physician-scientists have been skewed dramatically over the past decade, with the proportion of NIH-funded principal investigators in their 60s and 70s soaring and younger physician- scientists in marked decline. This shift is particularly noted in procedural disciplines, like pulmonary and critical care medicine, where lucrative clinical practices lure away talented doctors, who in another era would have entered academic medicine. At Stanford University, we seek to reverse this trend by inspiring individuals to enter discovery-based careers through exposure to a new and dynamic vision of science energized by brilliant new technologies emerging here and neighboring Silicon Valley. This new Stanford T32 Training Grant Proposal combines adult and pediatric pulmonary programs in order to select the most promising Trainees and provide an optimally diverse interdisciplinary training experience. Dr. Mark Nicolls, the adult chief and Dr. David Cornfield, the pediatric chief, will share Program Director responsibilities; each bringing unique and complementary skills to the leadership position. We have carefully screened 30 Mentors from the Stanford biomedical community with a strong track record of training and academic productivity. Based on the expertise of our Mentors, we have identified eight domains of excellence from which trainees can choose a primary focus for an individualized development plan. These research areas include: 1) Vascular Disease, 2) Stem Cells & Lung Development, 3) Genetics & Genomics, 4) Lung Injury & Repair, 5) Lung Microbiome, 6) Lung Cancer and 7) Outcomes Research, and 8) Imaging. The grant proposal outlines a process by which pulmonary/critical care fellows at Stanford are exposed to research areas, introduced to Mentors, and move through a selective process designed to identify Trainees with the best chance of success in academic medicine. We describe a well-supported and carefully constructed system of oversight to promote recruitment of underrepresented minorities. All T32 trainees will have an individualized development plan that includes a core curriculum and electives appropriate to their research domain. Through a longitudinal bimonthly T32 meeting lead by the PDs and quarterly informal meetings with T32 trainees, Mentors and PDs, Trainees will be immersed in a micro-culture of academic pulmonary medicine. A Scientific Oversight Committee will identify appropriate coursework and ensure ongoing and timely Trainee progress. We have assembled an experienced Internal Advisory Committee at Stanford and an acclaimed group, with strong Stanford ties, for the External Advisory Committee. We will utilize regular feedback from these groups, the Mentors and Trainees to identify programmatic strengths and weaknesses and reassess our processes to adjust, adapt and improve the T32 fellowship. While acknowledging the inherent challenges of retaining physicians in academic medicine, Stanford is particularly well poised to capture, develop and inspire the next generation of physician-scientists and clinical researchers.