Center on American Indian and Alaska Native Genomic Research

 描述(由申请人提供)：美洲印第安人和阿拉斯加原住民对基因组研究的关注，在非常真实的意义上，已经成为伦理、法律和社会影响学术的基础。遗憾的是，其中许多问题仍未得到解决。对样本和数据保护的担忧继续引起许多部落社区的关注，遗传信息的实际和潜在滥用问题也是如此。与此同时，许多部落正在科学和社会之间建立新的关系，特别是在日益普遍的部落研究办公室。我们的项目寻求通过部落和社区地点的联合体来探索这些构造。通过将这些与俄克拉荷马医学研究基金会的基因组研究专业知识以及俄克拉荷马大学的美国印第安人和阿拉斯加原住民健康研究、审议和美洲原住民研究相结合，我们寻求创建一个能够支持下一代研究人员创新研究和教育的跨学科中心，这些研究人员准备利用令人兴奋的生物医学创新来满足美国印第安人和阿拉斯加原住民社区的需求。我们有三个具体目标：1)在俄克拉荷马大学建立一个跨学科团队，研究基因组知识对美国印第安人和阿拉斯加原住民社区的伦理、法律和社会影响；2)建立一个部落和社区机构联盟，对美国印第安人和阿拉斯加原住民社区基因组研究的伦理、法律和社会影响进行以文化为基础的比较研究；以及3)在美国印第安人和阿拉斯加原住民社区创建一个关于基因组学伦理、法律和社会影响的综合教育计划。我们拟建的中心建立了基础设施，以支持部落和联邦系统中广泛的社区驱动的健康和医疗保健调查，并制定了明确的计划，在部落和大学组成的分支网络中播种多个研究项目。

 DESCRIPTION (provided by applicant): American Indian and Alaska Native concerns about genomic research have, in a very real sense, been foundational in ethical, legal, and social implications scholarship. Sadly, many of these issues remain unresolved. Concerns about the protection of samples and data continue to engage many tribal communities, as do problems with the actual and potential abuse of genetic information. At the same time, many tribes are creating new relationships between science and society, especially in tribal research offices that are increasingly common. Our project seeks to explore these formations through a consortium of tribal and community sites. By pairing these with expertise in genomic research at the Oklahoma Medical Research Foundation and American Indian and Alaska Native health research, deliberation, and Native American Studies at the University of Oklahoma, we seek to create an interdisciplinary center capable of supporting innovative research and education of the next generation of researchers poised to harness exciting innovations in biomedicine to the needs of American Indian and Alaska Native communities. We have three specific aims: 1) to develop a transdisciplinary team at the University of Oklahoma for research on the ethical, legal, and social implications of genomic knowledge for American Indian and Alaska Native communities; 2) to build a consortium of tribal and community-based institutions to conduct culturally grounded comparative research on the ethical, legal, and social implications of genomic research in American Indian and Alaska Native communities; and 3) to create an integrated educational program in the ethical, legal, and social implications of genomics in American Indian and Alaska Native communities. Our proposed center creates the infrastructure to support a broad range of community-driven inquiries into health and health care, in both tribal and federal systems, with an explicit plan to seed multiple research projects in a ramifying network of tribes and universities.