Center for Leadership in Environmental Awareness and Research

摘要：有证据表明，接触挥发性有机化合物(VOC)，如苯、甲苯、 乙苯、二甲苯(BTEX)、三氯乙烯(TCE)和四氯乙烯(PCE)是一种重要的 母子健康的决定因素，对早产(PTB)和相关不良影响的影响 健康结果。VOCs来自垃圾填埋场、棕地和超级基金场地，污染浅层土壤 以及居民区、商业区和工业区以下的地下水，导致通过蒸汽暴露 闯入。环境意识和研究领导中心(Clear)致力于 理解和缓解这一严重的环境健康问题，重点放在后工业城市 中锋。总部设在密歇根州底特律的Clear将把底特律作为研究地点，底特律的PTB最高 利率(15.2%)，所在的州67个超级基金站点中有37个必须管理VOC 污染。明确的假设是在生命早期通过蒸汽侵入接触VOC会激发 母体组织和/或发育中的子代的炎症反应对发育过程进行重新编程 免疫系统和其他关键系统，为肺结核和/或相关的不良健康后果奠定基础。五 综合环境科学、工程和生物医学研究项目(E1、E2、B1、B2、B3)， 由五个核心支持，将研究中毒机制、暴露途径、生物标记物和战略 通过以下方式预防暴露和改善公共卫生结果：(1)开发和测试新的检测方法 方法论，包括植物筛选(E1)；融合物联网和边缘的传感器技术 实时污染物检测和快速反应、缓解和补救的计算(E2)；以及 使用WSU设计的密封小室进行受控毒性生物测试，以评估生殖、神经、 斑马鱼的行为、免疫学和多世代反应(B1)；(2)机制效应研究 妊娠小鼠模型中VOC暴露的影响(B2)；(3)应用流行病学方法估计 通过人体生物样本分析的暴露效应(B3)；应用先进的化学分析，统计学 获取和整合项目数据(化学分析和数据)的方法和可视化工具 管理和分析核心)，从而确定VOC暴露对肺结核和相关 不利的健康后果；(4)创建跨学科教育和劳动力的创新模式 通过聘用新受训人员解决复杂的环境健康问题来实现多样性(研究经验 和培训协调核心)；(5)动员利益攸关方和社区为我们的查询/分析提供信息， 参与抽样，并采用卫生干预措施(社区参与核心)；和(6)联合 围绕着进行有针对性的研究翻译以确保科学遗产的管理核心 认识并支持超级基金研究计划，以改善受影响城市中心的公共卫生 通过环境污染保护受影响的社区。

Abstract: Evidence suggests that exposure to volatile organic compounds (VOCs), such as benzene, toluene, ethylbenzene, and xylene (BTEX), trichloroethylene (TCE), and tetrachloroethylene (PCE), is an important determinant of maternal-offspring health, with implications for preterm birth (PTB) and associated adverse health outcomes. VOCs emanate from landfills, brownfields, and Superfund sites, contaminating shallow soils and groundwater below residential, commercial, and industrial properties, leading to exposures via vapor intrusion. The Center for Leadership in Environmental Awareness and Research (CLEAR) is dedicated to understanding and mitigating this serious environmental health problem with a focus on post-industrial urban centers. Headquartered in Detroit, Michigan, CLEAR will use Detroit as a study site, which has the highest PTB rate in the country (15.2%) and is located in a state where 37 of the 67 Superfund sites must manage VOC contamination. CLEAR hypothesizes that VOC exposure through vapor intrusion during early life incites inflammatory responses in maternal tissues and/or the developing offspring that re-program the developing immune and other critical systems, setting the stage for PTB and/or associated adverse health outcomes. Five integrative environmental science and engineering and biomedical research projects (E1, E2, B1, B2, B3), supported by five cores, will investigate toxic mechanisms, exposure pathways, biomarkers, and strategies to prevent exposures and improve public health outcomes by: (1) developing and testing new detection methodologies, including phytoscreening (E1); sensor technology that integrates Internet of Things and edge computing for real-time contaminant detection and rapid-response, mitigation, and remediation (E2); and a controlled toxicity bioassay using WSU-designed sealed chambers for evaluating reproductive, neurological, behavioral, immunological and multigenerational responses in zebrafish (B1); (2) studying mechanistic effects of VOC exposure in a pregnant mouse model (B2); (3) applying epidemiologic methods for estimating exposure effects via human biological specimen analysis (B3); applying advanced chemical analysis, statistical approaches and visualization tools to obtain and integrate project data (Chemical Analysis, and Data Management and Analysis Cores), thereby establishing the impact of VOC exposures on PTB and associated adverse health outcomes; (4) creating an innovative model for transdisciplinary education and workforce diversity by engaging new trainees to solve complex environmental health problems (Research Experience and Training Coordination Core); (5) engaging stakeholders and the community to inform our inquiry/analysis, participate in sampling, and employ health interventions (Community Engagement Core); and (6) uniting around an Administrative Core that conducts targeted research translation to ensure a legacy of scientific awareness and supports the Superfund Research Program to improve public health in urban centers impacted by environmental contamination to protect affected communities.