Bone Histology and Imaging

项目摘要/摘要 阿肯色大学拟议的肌肉骨骼疾病研究中心(CMDR) 医学(UAMS)包括建立骨组织学和成像核心(核心C)。这个 拟议的CMDR的科学主题是确定疾病和状况的分子原因 这会对肌肉骨骼系统产生负面影响，或者作为疾病过程的一部分与该系统相互作用。 骨组织和成像核心与这一主题一致，因为它将交付给项目负责人 最先进的定量组织和细胞数据，用于表征结构、组织和细胞 正在研究的肌肉骨骼疾病的病理机制的变化。《骨头》 因此，组织学和成像核心将是项目负责人成功的关键组成部分。这个 CORE将把UAMS园区的现有设备整合到一个大型的现代化研究空间中 整形外科，并将聘请经验丰富的人员在校园内，这将是监督 由一位核心领导人领导。具体目标是：1)建立骨组织学和影像核心；2)交付 最先进的肌肉骨骼成像、生物力学测试和组织学服务，并推出新的 向CMDR项目负责人和教职员工提供分析技术；3)提供骨组织形态计量学培训和 支持教育活动。骨组织学和影像学核心的成功，与其他 CMDR核心，将支持发展一支关键的调查人员队伍，以确保长期 中心的可持续性和生产力。

PROJECT SUMMARY/ABSTRACT The proposed Center for Musculoskeletal Disease Research (CMDR) at the University of Arkansas for Medical Sciences (UAMS) includes the establishment of the Bone Histology and Imaging Core (Core C). The scientific theme of the proposed CMDR is the identification of the molecular causes of diseases and conditions that negatively impact the musculoskeletal system or interact with this system as part of their disease process. The Bone Histology and Imaging Core is consistent with this theme in that it will deliver to the Project Leaders state-of-the-art quantitative tissue and cellular data for the characterization of the structural, tissue, and cellular changes that underlie the pathological mechanisms of the musculoskeletal diseases being studied. The Bone Histology and Imaging Core will therefore be a critical component for the success of the Project Leaders. The Core will consolidate existing equipment on the UAMS campus into a large, modern research space within the Department of Orthopaedic Surgery and will hire experienced personnel on the campus, which will be supervised by a Core Leader. The specific aims are: 1) To establish the Bone Histology and Imaging Core; 2) To deliver state-of-the-art musculoskeletal imaging, biomechanical testing, and histology services and introduce new analytical technologies to CMDR Project Leaders and faculty; 3) To provide bone histomorphometry training and support educational activities. The success of the Bone Histology and Imaging Core, in conjunction with the other CMDR cores, will support the development of a critical mass of investigators that will ensure the long-term sustainability and productivity of the Center.